2024
Polygenic Risk of Epilepsy and Poststroke Epilepsy
Clocchiatti-Tuozzo S, Rivier C, Misra S, Zelano J, Mazumder R, Sansing L, de Havenon A, Hirsch L, Liebeskind D, Gilmore E, Sheth K, Kim J, Worrall B, Falcone G, Mishra N. Polygenic Risk of Epilepsy and Poststroke Epilepsy. Stroke 2024, 55: 2835-2843. PMID: 39502073, DOI: 10.1161/strokeaha.124.047459.Peer-Reviewed Original ResearchParticipants of European ancestryRisk of poststroke epilepsyPolygenic riskPoststroke epilepsyEuropean ancestryGenome-wide association study meta-analysisPRS decileCase-control genetic association studyGenetic risk lociLowest decilePolygenic risk scoresGenetic association studiesMultivariate logistic regression modelStudy meta-analysisMultivariate logistic regression resultsHistory of strokeLogistic regression modelsRisk lociAssociation studiesStroke survivorsUK BiobankGenetic informationGenetic ancestryLogistic regression resultsGenetic variantsImprovement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis
Sujijantarat N, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Jiang J, Hengartner A, Shekhar A, Amllay A, Nowicki K, Hebert R, Gilmore E, Sheth K, King J, Matouk C. Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis. Clinical Neurology And Neurosurgery 2024, 246: 108555. PMID: 39357321, DOI: 10.1016/j.clineuro.2024.108555.Peer-Reviewed Original ResearchStudy-level meta-analysisRate of improvementCN deficitsMeta-analysisIntracranial aneurysmsCN palsySystematic reviewFactors associated with recoveryPooled rateRandom-effects meta-analysisCranial nervesManual citation searchingEffects meta-analysisRate of clinical improvementCranial nerve palsyMechanism of injuryIncreased rate of improvementFlow diversionRare presenting symptomSymptomatic intracranial aneurysmsTreatment of intracranial aneurysmsCitation searchingPalsyNerve palsyRetrospective reviewVariability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial
Beekman R, Perman S, Nguyen C, Kline P, Clevenger R, Yeatts S, Ramakrishnan R, Geocadin R, Silbergleit R, Meurer W, Gilmore E. Variability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial. Resuscitation 2024, 203: 110397. PMID: 39278393, PMCID: PMC11466710, DOI: 10.1016/j.resuscitation.2024.110397.Peer-Reviewed Original ResearchCorrection: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group
Carroll E, Der‑Nigoghossian C, Alkhachroum A, Appavu B, Gilmore E, Kromm J, Rohaut B, Rosanova M, Sitt J, Claassen J. Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group. Neurocritical Care 2024, 1-2. PMID: 39187691, DOI: 10.1007/s12028-024-02100-4.Peer-Reviewed Original ResearchA practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors
Chan W, Nguyen C, Kim N, Tripodis Y, Gilmore E, Greer D, Beekman R. A practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors. Resuscitation 2024, 202: 110370. PMID: 39178939, DOI: 10.1016/j.resuscitation.2024.110370.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryDeep gray nucleiArea under the receiver operating curveMagnetic resonance imagingMagnetic Resonance Imaging ScorePoor neurological outcomeCerebral Performance CategoryIntra-class correlationNeurological outcomeMRI scoreCardiac arrestComatose CA survivorsCA survivorsComatose cardiac arrest survivorsPredicting neurologic outcomeCardiac arrest survivorsInter-rater reliabilityReceiver operating curveAcademic medical centerMedian timePoor outcomePrognostic toolGray nucleiArrest survivorsScore groupAntiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns.
Sivaraju A, Tao A, Jadav R, Kirunda K, Rampal N, Kim J, Gilmore E, Hirsch L. Antiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns. Neurology Clinical Practice 2024, 14: e200342. PMID: 39185097, PMCID: PMC11341085, DOI: 10.1212/cpj.0000000000200342.Peer-Reviewed Original ResearchCerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey
Greige T, Tao B, Dangayach N, Gilmore E, O’Hana Nobleza C, Hinson H, Chou S, Jha R, Wahlster S, Gebrewold M, Lele A, Ong C. Cerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey. Neurocritical Care 2024, 1-15. PMID: 39085504, DOI: 10.1007/s12028-024-02077-0.Peer-Reviewed Original ResearchCerebral edemaPractice variationLife-threatening complicationsAttending physiciansFactors associated with practice variationFisher's exact testCritically ill patientsUniversity-affiliated centerAcute brain injuryMonitoring cerebral edemaOsmotic therapyExact testDecompressive hemicraniectomyBackgroundCerebral edemaRadiographic findingsTreatment strategiesIll patientsRadiographic indicatorsPractice patternsUniversity affiliationEdemaSociety web sitesLogistic regressionProvider preferencesPractice surveyTemperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Kim N, Nguyen C, McGinniss G, Deng Y, Kitlen E, Garcia G, Wira C, Khosla A, Johnson J, Miller P, Perman S, Sheth K, Greer D, Gilmore E. Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2024, 84: 549-559. PMID: 39033449, DOI: 10.1016/j.annemergmed.2024.06.007.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestNeurological outcomeDevice cohortCardiac arrestOut-of-hospital cardiac arrest patientsConsecutive out-of-hospital cardiac arrestPreinduction timeInterquartile rangeAssociated with improved outcomesCardiac arrest patientsProportion of patientsMultivariate logistic regression modelInverse probability of treatmentDevice timeInverse probability treatment weightsProbability of treatmentProspective trialsOHCA patientsArrest patientsClinical outcomesLogistic regression modelsCenter studyEarly initiationSecondary outcomesTreatment weightingCerebral edema following cardiac arrest: Are all shades of gray equal?
Beekman R, Gilmore E. Cerebral edema following cardiac arrest: Are all shades of gray equal? Resuscitation 2024, 198: 110213. PMID: 38636600, DOI: 10.1016/j.resuscitation.2024.110213.Peer-Reviewed Original ResearchExploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004)
Olexa M, Begunova Y, Gilmore E, Kim J, Herman A, Beekman R, Magid-Bernstein J, Matouk C, Sheth K, Miller E, Gutierrez S, De Havenon A, Sansing L, Petersen N. Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205692.Peer-Reviewed Original ResearchPrognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010)
Wang E, Misra S, Yan J, Chook P, Kawamura Y, Kitagawa R, Kim J, Gilmore E, De Havenon A, Sivaraju A, Hirsch L, Falcone G, Sansing L, Magid-Bernstein J, Mishra N. Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204783.Peer-Reviewed Original ResearchAssociation of CT-based Lobar Contusion Volumes and Locations with Post-traumatic Epilepsy (P5-1.003)
Shrishail N, Wheelock J, Sanders W, Doherty D, Kim J, Schlecter M, Sivaraju A, Hirsch L, Omay S, Sheth K, Gilmore E, Edlow B, Kim J. Association of CT-based Lobar Contusion Volumes and Locations with Post-traumatic Epilepsy (P5-1.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206260.Peer-Reviewed Original ResearchLow-field, Portable Magnetic Resonance Imaging to Assess Hematoma Volume in Traumatic Brain Injury Patients (P10-5.008)
Zabinska J, Yadlapalli V, Mazurek M, Parasuram N, Lalwani D, Peasley E, Gilmore E, Kim J, Omay S, Sze G, Payabvash S, Sorby-Adams A, Iglesias J, Rosen M, Kimberly W, Sheth K. Low-field, Portable Magnetic Resonance Imaging to Assess Hematoma Volume in Traumatic Brain Injury Patients (P10-5.008). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000208210.Peer-Reviewed Original ResearchAssessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019)
Jayasundara S, Kim J, Choi R, Rapuano A, Barnes E, Parasram M, Moura M, Uppal P, Chen Y, Top I, Olexa M, Maarek R, Yan J, Beekman R, Magid-Bernstein J, Hebert R, Bahrassa F, Matouk C, Sheth K, Gilmore E, Petersen N. Assessing Effects of Intrathecal Nicardipine on Cerebral Autoregulation and Cortical Activity in Aneurysmal Subarachnoid Hemorrhage (P10-5.019). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206285.Peer-Reviewed Original ResearchCan Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001)
Nguyen C, Molligoda B, Kim N, Kitlen E, Wira C, Perman S, Khosla A, Miller P, Greer D, Gilmore E, Beekman R. Can Clinical Scores Predict the Presence of Hypoxic Ischemic Brain Injury on Early Head Computed Tomography After Cardiac Arrest? (P6-2.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206255.Peer-Reviewed Original ResearchThe Impact of Socioeconomic Status on Risk for Brain Death Following Out-of-Hospital Cardiac Arrest (P1-4.014)
Fung C, Kitlen E, Nguyen C, Kim N, Wira C, Perman S, Khosla A, Miller P, Greer D, Gilmore E, Beekman R. The Impact of Socioeconomic Status on Risk for Brain Death Following Out-of-Hospital Cardiac Arrest (P1-4.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206574.Peer-Reviewed Original ResearchVariability in Brain Death Education Across US Neurology Residency Programs (P6-7.008)
Doobay G, Barnes E, Moeller J, Gilmore E, Beekman R. Variability in Brain Death Education Across US Neurology Residency Programs (P6-7.008). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206169.Peer-Reviewed Original ResearchContinuous EEG Monitoring Practice Variation in TBI: Early Findings in the ELECTRO-BOOST Cohort (S23.009)
Piotrowski K, Webb A, MacDonald B, Rosenthal E, Gilmore E, Uppal P, Silbergleit R, Diaz-Arrastia R, Kim J, Yeatts S, Ding K. Continuous EEG Monitoring Practice Variation in TBI: Early Findings in the ELECTRO-BOOST Cohort (S23.009). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204536.Peer-Reviewed Original Research13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study
Woodward M, Brown J, Badjatia N, Morris N, Johnson E, Gilmore E. 13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study. Journal Of Clinical And Translational Science 2024, 8: 4-4. PMCID: PMC11023845, DOI: 10.1017/cts.2024.34.Peer-Reviewed Original ResearchHealth care providersWithdrawal of life-sustaining therapySuper-refractory status epilepticusHCP responsesAdvanced practice providersPerceived poor neurologic prognosisLife-sustaining therapyCountry of practiceTreating super-refractory status epilepticusHypothetical clinical casesRefractory status epilepticusLogistic regression modelsPractice providersCare providersSurveyed cliniciansCare escalationYears of experienceClinician-specific factorsMedical futilityPotential confoundersPoor neurologic prognosisRespondent demographicsStatus epilepticusInternational survey studyAssociated with high mortalityGuidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society
Frontera J, Gilmore E, Johnson E, Olson D, Rayi A, Tesoro E, Ullman J, Yuan Y, Zafar S, Rowe S. Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society. Neurocritical Care 2024, 40: 819-844. PMID: 38316735, DOI: 10.1007/s12028-023-01907-x.Peer-Reviewed Original ResearchModerate-severe TBITraumatic brain injuryGrading of recommendations assessmentAntiseizure medicationsResultsThe initial literature searchAdverse eventsHealth care professionalsBrain injuryClinical practice guidelinesMeta-analysis of articlesEffects of antiseizure medicationsEarly seizuresLate seizuresCare professionalsCognitive outcomesRecommendations AssessmentDuration of prophylaxisPractice guidelinesSystematic reviewProphylactic antiseizure medicationPICO 1Meta-analysisLiterature searchFunctional outcomesGrading criteria