2017
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood C, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron 2017, 95: 639-655.e10. PMID: 28712654, DOI: 10.1016/j.neuron.2017.06.028.Peer-Reviewed Original ResearchConceptsPV+ cellsPerineuronal netsInterneuron plasticityInterneuron functionActivity-dependent neuronal plasticityParvalbumin interneuron functionPNN proteinAMPA receptorsPotassium channelsNeuronal plasticityNervous systemBrevican levelsInterneuronsMolecular programsSynaptic formCellular modificationsMolecular mechanismsCellsBrevican
2014
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Annibali D, Whitfield J, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir N, Massó-Vallés D, Beaulieu M, Swigart L, Mc Gee M, Somma M, Nasi S, Seoane J, Evan G, Soucek L. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nature Communications 2014, 5: 4632. PMID: 25130259, PMCID: PMC4143920, DOI: 10.1038/ncomms5632.Peer-Reviewed Original ResearchConceptsMYC inhibitionElevated MYC levelsPatient-derived tumorsAdult central nervous systemHuman glioblastoma cell linesCentral nervous systemFormation of multinucleated cellsPrimary tumorGlioblastoma cell linesStandard therapyOrthotopic xenograftsMYC levelsMouse modelIncreased apoptosisCancer therapyHuman tumorsMitotic catastropheTherapeutic strategiesHuman gliomasMYCTumorNervous systemInvasive astrocytomasGliomaCell lines