2004
Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension
Kahle KT, MacGregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 14877-14882. PMID: 15465913, PMCID: PMC522037, DOI: 10.1073/pnas.0406172101.Peer-Reviewed Original ResearchConceptsPseudohypoaldosteronism type IIPHAII-mutant WNK4Paracellular fluxPotent antihypertensive agentTight junction proteinsTight junctionsAntihypertensive agentsParacellular ion fluxPharmacologic propertiesTight junction structureTranscellular transportersWild-type WNK4Normal physiologyHypertensionTransepithelial resistanceWNK signalingKidney epitheliumTight junction formationParacellular pathwayWNK4Effect of WNK4EpitheliumType IIWNK4 kinaseHomeostasis
1989
MECHANISMS OF WATER TRANSPORT BY EPITHELIAL CELLS
Tripathi S, Boulpaep E. MECHANISMS OF WATER TRANSPORT BY EPITHELIAL CELLS. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 1989, 74: 385-417. PMID: 2678220, DOI: 10.1113/expphysiol.1989.sp003288.Peer-Reviewed Original Research
1988
Cell membrane water permeabilities and streaming currents in Ambystoma proximal tubule
Tripathi S, Boulpaep E. Cell membrane water permeabilities and streaming currents in Ambystoma proximal tubule. American Journal Of Physiology 1988, 255: f188-f203. PMID: 3394810, DOI: 10.1152/ajprenal.1988.255.1.f188.Peer-Reviewed Original ResearchMeSH KeywordsAmbystomaAnimalsBody WaterCell Membrane PermeabilityElectrophysiologyFemaleKidney Tubules, ProximalReference Values
1987
pH-Dependent electrical properties and buffer permeability of theNecturus renal proximal tubule cell
Steels P, Boulpaep E. pH-Dependent electrical properties and buffer permeability of theNecturus renal proximal tubule cell. The Journal Of Membrane Biology 1987, 100: 165-182. PMID: 3430572, DOI: 10.1007/bf02209148.Peer-Reviewed Original Research
1979
Equivalent electrical circuit analysis and rheogenic pumps in epithelia.
Boulpaep E, Sackin H. Equivalent electrical circuit analysis and rheogenic pumps in epithelia. The FASEB Journal 1979, 38: 2030-6. PMID: 437145.Peer-Reviewed Original Research
1976
Electrical phenomena in the nephron
Boulpaep E. Electrical phenomena in the nephron. Kidney International 1976, 9: 88-102. PMID: 940266, DOI: 10.1038/ki.1976.14.Peer-Reviewed Original ResearchConceptsSingle barrierAvailable experimental dataIon movementElectrical conductanceElectrical phenomenaSingle cell membraneSingle membrane levelElectric currentElectrical propertiesPotential differenceExperimental dataDiffusion barrierDistinctive physical propertiesElectrical characteristicsPhysical propertiesIndividual cell membranesDiffusion boundariesElectrical behaviorPotential gradientMembrane approachConjugate forcesBiological membranesElectrochemical potential gradientTransport processesMicroscopic level
1974
Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney Tubule
Grandchamp A, Boulpaep E. Pressure Control of Sodium Reabsorption and Intercellular Backflux across Proximal Kidney Tubule. Journal Of Clinical Investigation 1974, 54: 69-82. PMID: 4834883, PMCID: PMC301525, DOI: 10.1172/jci107751.Peer-Reviewed Original Research
1973
Effects on intrarenal pressure on sodium reabsorption and the permeability of the route of intercellular shunt of the proximal tubule.
Grandchamp A, Boulpaep E. Effects on intrarenal pressure on sodium reabsorption and the permeability of the route of intercellular shunt of the proximal tubule. Minerva Nefrologica 1973, 20: 375. PMID: 4792774.Peer-Reviewed Original ResearchMeSH KeywordsCell Membrane PermeabilityHumansKidney Tubules, ProximalOsmolar ConcentrationPressureSodiumWater-Electrolyte Balance
1971
Electrolyte transport in kidney tubule cells
Giebisch G, Boulpaep E, Whittembury G. Electrolyte transport in kidney tubule cells. Philosophical Transactions Of The Royal Society B Biological Sciences 1971, 262: 175-196. PMID: 4399217, DOI: 10.1098/rstb.1971.0088.Peer-Reviewed Original ResearchConceptsTubule cellsTubular levelKidney tubule cellsNet Na transportActive K uptakePotassium secretionNa-K exchange pumpK secretionProximal tubular levelLuminal cell membraneElectrolyte transportNa pumpLines of evidenceTranstubular movementNa transportNet NaCell compartmentExchange pumpSecretionInterstitial fluidCellsLumenPassive leakIonic pumpsUptake