2018
Glycemic Variability and Brain Glucose Levels in T1DM
Hwang JJ, Jiang L, Sanchez Rangel E, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS. Glycemic Variability and Brain Glucose Levels in T1DM. Diabetes 2018, 68: db180722. PMID: 30327383, PMCID: PMC6302539, DOI: 10.2337/db18-0722.Peer-Reviewed Original ResearchConceptsBrain glucose levelsGlycemic variabilityGlucose levelsHyperglycemic clampType 1 diabetes mellitusPlasma glucose levelsBrain glucose transportHealthy control participantsDiabetes mellitusBrain glucoseControl ratsContinuous glucose monitorGlucose clampRat modelOccipital lobeMRS scanningT1DMGlucose kineticsControl participantsGlucose transport kineticsGlucose monitorSimilar changesRatsClampGlucose transport
2017
Metformin: clinical use in type 2 diabetes
Sanchez-Rangel E, Inzucchi SE. Metformin: clinical use in type 2 diabetes. Diabetologia 2017, 60: 1586-1593. PMID: 28770321, DOI: 10.1007/s00125-017-4336-x.Peer-Reviewed Original ResearchConceptsGlucose-lowering effectType 2 diabetesModerate chronic kidney diseaseOral glucose-lowering medicationsNew glucose-lowering drugsType 2 diabetes mellitusOptimal initial therapyGlucose-lowering medicationsChronic kidney diseaseFirst-line treatmentGlucose-lowering drugsGood safety profilePrecise mechanismHepatic glucose productionMore robust evidenceFoundation therapyInitial therapyCardiovascular eventsInflammatory markersRenal dysfunctionDiabetes mellitusWeight neutralityKidney diseaseSafety profileGlucose production