2024
The association between salivary oxytocin, age, and puberty in children with and without OCD
Mora-Jensen A, Clemmensen L, Grønberg M, Lebowitz E, Quintana D, Jørgensen N, Larsen C, Bak L, Christensen G, Pretzmann L, Uhre V, Christensen S, Uhre C, Korsbjerg N, Thoustrup C, Hagstrøm J, Ritter M, Plessen K, Pagsberg A, Lønfeldt N. The association between salivary oxytocin, age, and puberty in children with and without OCD. Scientific Reports 2024, 14: 28693. PMID: 39562644, PMCID: PMC11576962, DOI: 10.1038/s41598-024-80194-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOxytocin concentrationsPediatric obsessive-compulsive disorderSalivary oxytocin concentrationsVisual inspection of plotsOxytocin systemPsychiatric disordersSalivary oxytocinEnzyme-linked immunosorbent assayBehavioral changesPubertal stageAdolescentsModerate supportOxytocinInconsistent resultsPost-hocDisordersChildrenPost hoc testSystem activityCovariates ageParentsAssociationImmunosorbent assayHypothesis
2023
Affective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task
Nook E, Nardini C, Zacharek S, Hommel G, Spencer H, Martino A, Morra A, Flores S, Anderson T, Marin C, Silverman W, Lebowitz E, Gee D. Affective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task. Emotion 2023, 23: 1513-1521. PMID: 36595385, PMCID: PMC10314965, DOI: 10.1037/emo0001203.Peer-Reviewed Original ResearchConceptsNegative affect wordsChallenging puzzle taskAffect wordsAffective languagePuzzle taskEffective emotion regulationSpread of emotionsEmotion regulationNeuroscientific levelAnxious childrenEmotional influencesWord useBidirectional influenceAnxiety disordersBidirectional relationsMother's directionsMental healthEmotionsFuture researchWordsCurrent studyLanguageChildrenTaskMothersParent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome
Cabrera V, Buitron V, Patriarca G, Rey Y, Lebowitz E, Silverman W, Pettit J. Parent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome. Behavior Therapy 2023, 54: 852-862. PMID: 37597962, PMCID: PMC10440415, DOI: 10.1016/j.beth.2023.03.002.Peer-Reviewed Original ResearchConceptsYouth anxiety severityParent accommodationCognitive-behavioral treatmentYouth irritabilityAnxiety treatment outcomesAnxiety severityChild anxietyPrimary anxiety disorder diagnosisAnxiety disorder diagnosisAnxious youthYouth anxietyYouth ages 6Adolescent irritabilityAnxiety outcomesBehavioral treatmentAnxiety protocolAnxietyGreater impairmentDisorder diagnosisAge 6Treatment outcomesFuture researchPosttreatmentIrritabilityResearch documentsMaternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels
Lebowitz E, Marin C, Orbach M, Salmaso N, Vaccarino F, Silverman W. Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels. Journal Of Affective Disorders 2023, 326: 193-197. PMID: 36717031, PMCID: PMC10104478, DOI: 10.1016/j.jad.2023.01.090.Peer-Reviewed Original ResearchConceptsFGF2 levelsDepressive symptomsDepression symptomsChild anxietySymptoms of anxietyRatings of anxietyGrowth factor 2Maternal anxietySymptomsDepressed childrenDepressionChild depressionMothersChildrenFactor 2Self-report ratingsAnxietyIntergenerational pathwaysNon-referred childrenRange of anxietyFGF2AssociationLevelsMaternal
2020
Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder
Zhang Y, Liu W, Lebowitz ER, Zhang F, Hu Y, Liu Z, Yang H, Wu J, Wang Y, Silverman WK, Yang Z, Cheng W. Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder. Neuropharmacology 2020, 180: 108301. PMID: 32910952, DOI: 10.1016/j.neuropharm.2020.108301.Peer-Reviewed Original ResearchConceptsThalamic volumeThalamic asymmetryAge group differencesAbnormal asymmetryAnxiety disordersBilateral thalamic volumeAnxiety symptomsBrain developmental abnormalitiesOlder age groupsSocial anxiety disorderChronic family stressMedication-free childrenFunctional lateralizationMental disordersAge groupsChronic stressBrain developmentTotal SCARED scoresDisordersFamilial stressChildrenAnxiety severityAdolescentsEmotional disordersDevelopmental abnormalitiesA computational network perspective on pediatric anxiety symptoms
Abend R, Bajaj MA, Coppersmith DDL, Kircanski K, Haller SP, Cardinale EM, Salum GA, Wiers RW, Salemink E, Pettit JW, Pérez-Edgar K, Lebowitz ER, Silverman WK, Bar-Haim Y, Brotman MA, Leibenluft E, Fried EI, Pine DS. A computational network perspective on pediatric anxiety symptoms. Psychological Medicine 2020, 51: 1752-1762. PMID: 32787994, PMCID: PMC8486314, DOI: 10.1017/s0033291720000501.Peer-Reviewed Original ResearchBirth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study
Lønfeldt NN, Strandberg-Larsen K, Verhulst FC, Plessen KJ, Lebowitz ER. Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study. Journal Of Affective Disorders 2020, 274: 112-117. PMID: 32469793, DOI: 10.1016/j.jad.2020.04.067.Peer-Reviewed Original ResearchConceptsChildhood emotional disordersSynthetic oxytocinNationwide register-based cohort studyDanish Medical Birth RegisterRegister-based cohort studyDanish population-based studyEmotional disordersSelective serotonin reuptake inhibitorsMedical Birth RegisterSerotonin reuptake inhibitorsPopulation-based studyUse of oxytocinRevision of guidelinesCrude Cox modelPrescription RegistryTraumatic Stress DisorderCohort studyLabor inductionReuptake inhibitorsDanish patientsSmoking statusObsessive-compulsive disorderBirth RegisterMaternal historyCox modelParent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment
Zilcha-Mano S, Shimshoni Y, Silverman WK, Lebowitz ER. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 427-439. PMID: 32401557, PMCID: PMC8496486, DOI: 10.1080/15374416.2020.1756300.Peer-Reviewed Original ResearchConceptsParent-child agreementFamily accommodationMultilevel response-surface analysisAnxious Childhood EmotionsChild anxiety treatmentChild anxiety severityCognitive behavioral therapyAnxiety symptom severityDistinct underlying mechanismsChildhood EmotionsChildhood anxietySupportive parentingAnxiety treatmentParent reportBehavioral therapyRole of accommodationAnxiety severityAnxiety disordersPoor treatment outcomesTreatment outcomesSymptom severitySubsequent treatment outcomesTreatment endSignificant predictorsChildrenThe Relationship of Family Accommodation with Pediatric Anxiety Severity: Meta-analytic Findings and Child, Family and Methodological Moderators
Iniesta-Sepúlveda M, Rodríguez-Jiménez T, Lebowitz ER, Goodman WK, Storch EA. The Relationship of Family Accommodation with Pediatric Anxiety Severity: Meta-analytic Findings and Child, Family and Methodological Moderators. Child Psychiatry & Human Development 2020, 52: 1-14. PMID: 32246361, DOI: 10.1007/s10578-020-00987-6.Peer-Reviewed Original Research
2019
Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety?
Shimshoni Y, Lebowitz ER, Brotman MA, Pine DS, Leibenluft E, Silverman WK. Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety? Behavior Therapy 2019, 51: 211-222. PMID: 32138933, PMCID: PMC7080292, DOI: 10.1016/j.beth.2019.06.005.Peer-Reviewed Original ResearchMeasuring Family Accommodation of Childhood Anxiety: Confirmatory Factor Analysis, Validity, and Reliability of the Parent and Child Family Accommodation Scale – Anxiety
Lebowitz ER, Marin CE, Silverman WK. Measuring Family Accommodation of Childhood Anxiety: Confirmatory Factor Analysis, Validity, and Reliability of the Parent and Child Family Accommodation Scale – Anxiety. Journal Of Clinical Child & Adolescent Psychology 2019, 49: 752-760. PMID: 31136200, PMCID: PMC6881529, DOI: 10.1080/15374416.2019.1614002.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisFamily accommodationChildhood anxietyExploratory factor analysisTest-retest reliabilityFactor analysisChild anxiety symptomsChild depression symptomsChild-parent dyadsTwo-factor modelTest-retest reliability dataChild anxietyAnxiety symptomsFamily routinesDivergent validityDepression symptomsTest-retest dataConvergent validityFactorial structureKey constructsAnxietyAccommodation measuresTheory developmentClinical applicationStudy objectiveFamily Accommodation in Autism Spectrum Disorder
Feldman I, Koller J, Lebowitz ER, Shulman C, Ben Itzchak E, Zachor DA. Family Accommodation in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3602-3610. PMID: 31134428, DOI: 10.1007/s10803-019-04078-x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFamily accommodationSpectrum disorderAnxiety disordersParent-based interventionsFamilies of childrenParents of childrenParental accommodationChild's RRBsRRB severityGreater symptom severityRepetitive behaviorsLower functioningHighlight avenuesPoor treatment outcomesRRBsSymptom severityChildrenMost participantsDisordersTreatment outcomesOCDHigh levelsFunctioningAccommodationParent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions
Lebowitz ER, Marin C, Martino A, Shimshoni Y, Silverman WK. Parent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 362-372. PMID: 30851397, PMCID: PMC6732048, DOI: 10.1016/j.jaac.2019.02.014.Peer-Reviewed Original ResearchConceptsParent-based treatmentAnxious Childhood EmotionsChildhood anxiety disordersFamily accommodationChildhood anxietyAnxiety disordersChildhood EmotionsSupportive parentingParenting stressAnxiety outcomesCognitive behavioral therapyPrimary anxiety disorderParent interventionBehavioral therapyChildren's ratingsAnxiety severityTreatment credibilityClinician-rated scalesParent treatmentParent involvementAnxietyDiagnostic InterviewEmotionsParentingIndependent evaluatorsFamily accommodation mediates nightmares and sleep-related problems in anxious children
Lebowitz ER, Shimshoni Y, Silverman WK. Family accommodation mediates nightmares and sleep-related problems in anxious children. Journal Of Anxiety Disorders 2019, 62: 94-99. PMID: 30660831, PMCID: PMC6432767, DOI: 10.1016/j.janxdis.2019.01.004.Peer-Reviewed Original ResearchConceptsSleep-related problemsAnxious childrenFamily accommodationHypothesized mediational pathwaysStructural equation modelingStructural equation modelChildhood anxietyMediational pathwaysFirst empirical evidenceMaternal reportsEquation modelingFit indicesNightmaresEquation modelChildrenEmpirical evidenceEmpirical dataAnxietyAccommodationParticipants
2018
Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis
Lønfeldt NN, Verhulst FC, Strandberg-Larsen K, Plessen KJ, Lebowitz ER. Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis. Psychological Medicine 2018, 49: 881-890. PMID: 30444210, DOI: 10.1017/s0033291718003021.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderPooled risk estimatesCognitive impairmentRisk estimatesNewcastle-Ottawa Quality Assessment ScaleNarrative summaryQuality Assessment ScaleNeurodevelopment of childrenUse of oxytocinAutism spectrum disorderEnglish-language studiesQuality of studiesIndependent risk estimatesOxytocin exposureLabor inductionObstetric guidelinesObservational studyNeurodevelopmental problemsPsychiatric symptomsDate restrictionsCurrent evidenceSystematic reviewAssessment ScaleAvailable evidenceHyperactivity disorderNegative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimizationSymptom Insight in Pediatric Obsessive-Compulsive Disorder: Outcomes of an International Aggregated Cross-Sectional Sample
Selles RR, Højgaard DRMA, Ivarsson T, Thomsen PH, McBride N, Storch EA, Geller D, Wilhelm S, Farrell LJ, Waters AM, Mathieu S, Lebowitz E, Elgie M, Soreni N, Stewart SE. Symptom Insight in Pediatric Obsessive-Compulsive Disorder: Outcomes of an International Aggregated Cross-Sectional Sample. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 615-619.e5. PMID: 30071984, PMCID: PMC7176075, DOI: 10.1016/j.jaac.2018.04.012.Peer-Reviewed Original ResearchUsing Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change
Lebowitz ER, François B. Using Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change. Behavior Therapy 2018, 49: 853-865. PMID: 30316485, PMCID: PMC6394864, DOI: 10.1016/j.beth.2018.04.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral avoidanceThreat facesMotion-tracking technologyChild-rated anxiety symptomsChildhood anxiety disordersSelf-rated fearAnxiety symptom severitySpider stimuliAnxious childrenTest-retest correlationsAreas of psychopathologyState anxietyTest-retest reliabilityAnxiety symptomsAnxiety disordersTime-effective measurementsAvoidance behaviorPsychometric propertiesTreatment-related changesSymptom severityThird studySecond studyAvoidanceLarge sample
2017
Maternal Acceptance Moderates Fear Ratings and Avoidance Behavior in Children
Shimshoni Y, Silverman WK, Byrne SP, Lebowitz ER. Maternal Acceptance Moderates Fear Ratings and Avoidance Behavior in Children. Child Psychiatry & Human Development 2017, 49: 460-467. PMID: 29188403, PMCID: PMC5871552, DOI: 10.1007/s10578-017-0765-5.Peer-Reviewed Original ResearchConceptsChildren’s avoidance behaviorMaternal acceptanceAvoidance behaviorBehavioral avoidanceAnxiety disordersFear of spidersSelf-rated fearLevel of avoidanceSpider stimuliAnxious childrenChild avoidanceChildren's fearsChildren's feelingsFearAvoidanceChildrenHallmark featureMothersAcceptanceDisordersAdolescentsBehaviorStimuliFeelingsModeratesMonotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study
Taylor JH, Lebowitz ER, Jakubovski E, Coughlin CG, Silverman WK, Bloch MH. Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study. Journal Of Clinical Child & Adolescent Psychology 2017, 47: 266-281. PMID: 28956620, PMCID: PMC6191182, DOI: 10.1080/15374416.2017.1371028.Peer-Reviewed Original ResearchConceptsChild/Adolescent Anxiety Multimodal StudyCognitive behavioral therapyModerators of outcomeSevere anxietyCombination of CBTIndependent evaluator ratingsMultimodal studyParent-rated anxietySeparation anxiety disorderMain effect findingsObsessive-compulsive disorderAnxious youthSocial anxietyChild anxietyBehavioral therapyAnxiety severityPill placeboAnxiety disordersEvaluators' ratingsAnxietyModeratorSocioeconomic statusLow socioeconomic statusYouthEffect findings