2024
The association between salivary oxytocin, age, and puberty in children with and without OCD
Mora-Jensen A, Clemmensen L, Grønberg M, Lebowitz E, Quintana D, Jørgensen N, Larsen C, Bak L, Christensen G, Pretzmann L, Uhre V, Christensen S, Uhre C, Korsbjerg N, Thoustrup C, Hagstrøm J, Ritter M, Plessen K, Pagsberg A, Lønfeldt N. The association between salivary oxytocin, age, and puberty in children with and without OCD. Scientific Reports 2024, 14: 28693. PMID: 39562644, PMCID: PMC11576962, DOI: 10.1038/s41598-024-80194-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOxytocin concentrationsPediatric obsessive-compulsive disorderSalivary oxytocin concentrationsVisual inspection of plotsOxytocin systemPsychiatric disordersSalivary oxytocinEnzyme-linked immunosorbent assayBehavioral changesPubertal stageAdolescentsModerate supportOxytocinInconsistent resultsPost-hocDisordersChildrenPost hoc testSystem activityCovariates ageParentsAssociationImmunosorbent assayHypothesisResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Assessing Anxiety-Related Impairment in Children and Adolescents
Etkin R, Lebowitz E, Silverman W. Assessing Anxiety-Related Impairment in Children and Adolescents. Assessment 2023, 31: 94-109. PMID: 37840296, DOI: 10.1177/10731911231194972.Peer-Reviewed Original ResearchConceptsAnxiety-related impairmentDoes Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships?
Etkin R, Juel E, Lebowitz E, Silverman W. Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships? Clinical Child And Family Psychology Review 2023, 26: 1052-1076. PMID: 37838627, DOI: 10.1007/s10567-023-00454-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive behavioral therapyAdolescent anxiety disordersPeer relationshipsSocial functioningAnxiety disordersYouth anxiety disordersPeer outcomesAnxiety reductionTreatment-specific effectsFunctioningTreatment specificitySystematic narrative reviewRelated difficultiesSample characteristicsMajority of studiesSpecific outcomesChildrenTreatment outcomesStatistical findingsStudy sampleDisordersNarrative reviewFindingsRelationshipAnxietyParent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome
Cabrera V, Buitron V, Patriarca G, Rey Y, Lebowitz E, Silverman W, Pettit J. Parent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome. Behavior Therapy 2023, 54: 852-862. PMID: 37597962, PMCID: PMC10440415, DOI: 10.1016/j.beth.2023.03.002.Peer-Reviewed Original ResearchConceptsYouth anxiety severityParent accommodationCognitive-behavioral treatmentYouth irritabilityAnxiety treatment outcomesAnxiety severityChild anxietyPrimary anxiety disorder diagnosisAnxiety disorder diagnosisAnxious youthYouth anxietyYouth ages 6Adolescent irritabilityAnxiety outcomesBehavioral treatmentAnxiety protocolAnxietyGreater impairmentDisorder diagnosisAge 6Treatment outcomesFuture researchPosttreatmentIrritabilityResearch documentsMaternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels
Lebowitz E, Marin C, Orbach M, Salmaso N, Vaccarino F, Silverman W. Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels. Journal Of Affective Disorders 2023, 326: 193-197. PMID: 36717031, PMCID: PMC10104478, DOI: 10.1016/j.jad.2023.01.090.Peer-Reviewed Original ResearchConceptsFGF2 levelsDepressive symptomsDepression symptomsChild anxietySymptoms of anxietyRatings of anxietyGrowth factor 2Maternal anxietySymptomsDepressed childrenDepressionChild depressionMothersChildrenFactor 2Self-report ratingsAnxietyIntergenerational pathwaysNon-referred childrenRange of anxietyFGF2AssociationLevelsMaternal
2022
Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth
Pettit J, Rey Y, Marin C, Bechor M, Lebowitz E, Vasey M, Jaccard J, Abend R, Pine D, Bar-Haim Y, Silverman W. Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth. Behavior Therapy 2022, 54: 77-90. PMID: 36608979, PMCID: PMC9825787, DOI: 10.1016/j.beth.2022.07.004.Peer-Reviewed Original ResearchConceptsAttention Bias Modification TreatmentAttention control trainingAttention trainingAnxiety severityAttention controlAnxiety levelsAttention biasNeutral facesLow-intensity treatmentGlobal impairmentDot-probe taskYouth anxiety severityClinic-Referred YouthFull criteriaAttention focusingControl trainingTreatment researchYouthIndependent evaluatorsTrainingImpairment ratingsACT trialsPosttreatmentSeverity ratingsRatings
2020
Using Evaluative Criteria to Review Youth Anxiety Measures, Part I: Self-Report
Etkin RG, Shimshoni Y, Lebowitz ER, Silverman WK. Using Evaluative Criteria to Review Youth Anxiety Measures, Part I: Self-Report. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 58-76. PMID: 32915074, PMCID: PMC7914129, DOI: 10.1080/15374416.2020.1802736.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildHumansPsychometricsReproducibility of ResultsSelf ReportConceptsSelf-report measuresYouth self-report measuresYouth Anxiety MeasureEvidence-based treatment deliveryPsychological scienceAnxiety measuresSelf-ReportEvidence-based assessmentPsychometric propertiesEvaluative reviewMost ratingsEvaluative criteriaEvidence-based updateFuture directionsRatingsMeasuresEvidence baseTreatment deliveryAnxietyHigh confidenceAssessment functionDisordersConfidenceAbnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder
Zhang Y, Liu W, Lebowitz ER, Zhang F, Hu Y, Liu Z, Yang H, Wu J, Wang Y, Silverman WK, Yang Z, Cheng W. Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder. Neuropharmacology 2020, 180: 108301. PMID: 32910952, DOI: 10.1016/j.neuropharm.2020.108301.Peer-Reviewed Original ResearchConceptsThalamic volumeThalamic asymmetryAge group differencesAbnormal asymmetryAnxiety disordersBilateral thalamic volumeAnxiety symptomsBrain developmental abnormalitiesOlder age groupsSocial anxiety disorderChronic family stressMedication-free childrenFunctional lateralizationMental disordersAge groupsChronic stressBrain developmentTotal SCARED scoresDisordersFamilial stressChildrenAnxiety severityAdolescentsEmotional disordersDevelopmental abnormalitiesDisparities in Mental and Behavioral Health Treatment for Children and Youth in Immigrant Families
Rosenberg J, Rosenthal MS, Cramer LD, Lebowitz ER, Sharifi M, Yun K. Disparities in Mental and Behavioral Health Treatment for Children and Youth in Immigrant Families. Academic Pediatrics 2020, 20: 1148-1156. PMID: 32599347, PMCID: PMC7655594, DOI: 10.1016/j.acap.2020.06.013.Peer-Reviewed Original ResearchConceptsOdds of receiptBehavioral health servicesBehavioral health treatmentAttention deficit hyperactivity disorder (ADHD) diagnosisPrimary outcomeUnique psychosocial stressorsChild healthHealth treatmentMedicationsHispanic/LatinxHealth servicesPsychosocial stressorsDisorder diagnosisMultiple covariatesTreatmentChildrenNational surveyUS parentsRepresentative surveyHealthSurvey respondentsReceiptDifferencesDiagnosisParent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment
Zilcha-Mano S, Shimshoni Y, Silverman WK, Lebowitz ER. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 427-439. PMID: 32401557, PMCID: PMC8496486, DOI: 10.1080/15374416.2020.1756300.Peer-Reviewed Original ResearchConceptsParent-child agreementFamily accommodationMultilevel response-surface analysisAnxious Childhood EmotionsChild anxiety treatmentChild anxiety severityCognitive behavioral therapyAnxiety symptom severityDistinct underlying mechanismsChildhood EmotionsChildhood anxietySupportive parentingAnxiety treatmentParent reportBehavioral therapyRole of accommodationAnxiety severityAnxiety disordersPoor treatment outcomesTreatment outcomesSymptom severitySubsequent treatment outcomesTreatment endSignificant predictorsChildrenThe Relationship of Family Accommodation with Pediatric Anxiety Severity: Meta-analytic Findings and Child, Family and Methodological Moderators
Iniesta-Sepúlveda M, Rodríguez-Jiménez T, Lebowitz ER, Goodman WK, Storch EA. The Relationship of Family Accommodation with Pediatric Anxiety Severity: Meta-analytic Findings and Child, Family and Methodological Moderators. Child Psychiatry & Human Development 2020, 52: 1-14. PMID: 32246361, DOI: 10.1007/s10578-020-00987-6.Peer-Reviewed Original Research
2019
Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety?
Shimshoni Y, Lebowitz ER, Brotman MA, Pine DS, Leibenluft E, Silverman WK. Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety? Behavior Therapy 2019, 51: 211-222. PMID: 32138933, PMCID: PMC7080292, DOI: 10.1016/j.beth.2019.06.005.Peer-Reviewed Original ResearchMeasuring Family Accommodation of Childhood Anxiety: Confirmatory Factor Analysis, Validity, and Reliability of the Parent and Child Family Accommodation Scale – Anxiety
Lebowitz ER, Marin CE, Silverman WK. Measuring Family Accommodation of Childhood Anxiety: Confirmatory Factor Analysis, Validity, and Reliability of the Parent and Child Family Accommodation Scale – Anxiety. Journal Of Clinical Child & Adolescent Psychology 2019, 49: 752-760. PMID: 31136200, PMCID: PMC6881529, DOI: 10.1080/15374416.2019.1614002.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisFamily accommodationChildhood anxietyExploratory factor analysisTest-retest reliabilityFactor analysisChild anxiety symptomsChild depression symptomsChild-parent dyadsTwo-factor modelTest-retest reliability dataChild anxietyAnxiety symptomsFamily routinesDivergent validityDepression symptomsTest-retest dataConvergent validityFactorial structureKey constructsAnxietyAccommodation measuresTheory developmentClinical applicationStudy objectiveFamily Accommodation in Autism Spectrum Disorder
Feldman I, Koller J, Lebowitz ER, Shulman C, Ben Itzchak E, Zachor DA. Family Accommodation in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3602-3610. PMID: 31134428, DOI: 10.1007/s10803-019-04078-x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFamily accommodationSpectrum disorderAnxiety disordersParent-based interventionsFamilies of childrenParents of childrenParental accommodationChild's RRBsRRB severityGreater symptom severityRepetitive behaviorsLower functioningHighlight avenuesPoor treatment outcomesRRBsSymptom severityChildrenMost participantsDisordersTreatment outcomesOCDHigh levelsFunctioningAccommodationFamily accommodation mediates nightmares and sleep-related problems in anxious children
Lebowitz ER, Shimshoni Y, Silverman WK. Family accommodation mediates nightmares and sleep-related problems in anxious children. Journal Of Anxiety Disorders 2019, 62: 94-99. PMID: 30660831, PMCID: PMC6432767, DOI: 10.1016/j.janxdis.2019.01.004.Peer-Reviewed Original ResearchConceptsSleep-related problemsAnxious childrenFamily accommodationHypothesized mediational pathwaysStructural equation modelingStructural equation modelChildhood anxietyMediational pathwaysFirst empirical evidenceMaternal reportsEquation modelingFit indicesNightmaresEquation modelChildrenEmpirical evidenceEmpirical dataAnxietyAccommodationParticipants
2018
The SPACE program, a parent-based treatment for childhood and adolescent OCD: The case of Jasmine.
Lebowitz ER, Shimshoni Y. The SPACE program, a parent-based treatment for childhood and adolescent OCD: The case of Jasmine. Bulletin Of The Menninger Clinic 2018, 82: 266-287. PMID: 30589579, DOI: 10.1521/bumc.2018.82.4.266.Peer-Reviewed Original ResearchConceptsParent-based treatmentCurrent evidence-based treatmentsCognitive behavioral therapyObsessive-compulsive disorderEvidence-based treatmentsChild avoidFamily accommodationResponse preventionLack of motivationSupportive responsesAdolescent OCDOwn behaviorChildren's symptomsPsychopharmacological treatmentYouthDisordersOCDAdolescentsDistressMotivationCase descriptionTheoretical backgroundParentsSymptomsChildrenNegative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimizationUsing Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change
Lebowitz ER, François B. Using Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change. Behavior Therapy 2018, 49: 853-865. PMID: 30316485, PMCID: PMC6394864, DOI: 10.1016/j.beth.2018.04.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral avoidanceThreat facesMotion-tracking technologyChild-rated anxiety symptomsChildhood anxiety disordersSelf-rated fearAnxiety symptom severitySpider stimuliAnxious childrenTest-retest correlationsAreas of psychopathologyState anxietyTest-retest reliabilityAnxiety symptomsAnxiety disordersTime-effective measurementsAvoidance behaviorPsychometric propertiesTreatment-related changesSymptom severityThird studySecond studyAvoidanceLarge sampleImplications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersChildHumansNational Institute of Mental Health (U.S.)United StatesConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach