2024
Brain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectome
2020
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C. Functional brain connectivity in ex utero premature infants compared to in utero fetuses. NeuroImage 2020, 219: 117043. PMID: 32534962, PMCID: PMC7493786, DOI: 10.1016/j.neuroimage.2020.117043.Peer-Reviewed Original ResearchConceptsPremature infantsHealthy fetusesBrain connectivityStructural brain injuryBlood oxygenation level-dependent (BOLD) signalBrain structural changesStress-related areasNormal brain MRIState functional MRIFunctional connectivity strengthFunctional brain connectivityLevel-dependent signalMedial temporal lobeNetwork-based statisticsSeed-based correlation analysisUtero fetusesBasal gangliaBrain injuryTerm ageBrain MRITemporal lobeExposure altersInfantsRegion of interestFunctional MRI
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAge