Divyesh Joshi
Associate Research ScientistAbout
Research
Publications
2026
Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease
Joshi D, Rukhlenko O, Tuliakova A, Sun Z, Bhogale T, Furtado J, Traylor J, Imoto H, Orr A, Tellides G, Martin K, Kholodenko B, Schwartz M. Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2603888123. PMID: 42673460, PMCID: PMC13552879, DOI: 10.1073/pnas.2603888123.Peer-Reviewed Original ResearchFOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis
Zhang X, Wang Y, Joshi D, Tellides G, Schwartz M. FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis. Circulation Research 2026, 138: e327592. PMID: 41738126, PMCID: PMC12989233, DOI: 10.1161/circresaha.125.327592.Peer-Reviewed Original ResearchElectrochemically integrated 2D borophene–graphene architectures for energy and antimicrobial applications
Pandey R, Pandey H, Andola A, Joshi D, Fujii M, Prakash A, Nakanishi H, Pandey R. Electrochemically integrated 2D borophene–graphene architectures for energy and antimicrobial applications. Nanoscale 2026, 18: 1055-1070. PMID: 41399897, DOI: 10.1039/d5nr03949e.Peer-Reviewed Original Research
2025
Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development
Joshi D, Jindal P, Shetty R, Inamdar M. Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development. ELife 2025, 13: rp98257. PMID: 40372775, PMCID: PMC12080998, DOI: 10.7554/elife.98257.Peer-Reviewed Original ResearchRudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development
Joshi D, Jindal P, Shetty R, Inamdar M. Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development. ELife 2025, 13 DOI: 10.7554/elife.98257.4.Peer-Reviewed Original ResearchcSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling
Rukhlenko O, Joshi D, Hu X, Junk P, Tuliakova A, Kholodenko B, Schwartz M. cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling. Science Advances 2025, 11: eado9970. PMID: 39752487, PMCID: PMC11698091, DOI: 10.1126/sciadv.ado9970.Peer-Reviewed Original Research
2024
Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis
Joshi D, Yang Z, Babar M, Meredith E, Attanasio J, Joshi N, Traylor J, Orr A, Fernandez-Hernando C, Libreros S, Schwartz M. Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis. Nature Cardiovascular Research 2024, 3: 1035-1048. PMID: 39232138, PMCID: PMC11399086, DOI: 10.1038/s44161-024-00522-z.Peer-Reviewed Original ResearchA KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling
Zhang J, Wang Y, Joshi D, Pi X, De Val S, Schwartz M. A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling. Nature Cardiovascular Research 2024, 3: 785-798. PMID: 39196179, PMCID: PMC12306366, DOI: 10.1038/s44161-024-00496-y.Peer-Reviewed Original ResearchLatrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz M. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. The EMBO Journal 2024, 43: 3175-3191. PMID: 38886581, PMCID: PMC11294477, DOI: 10.1038/s44318-024-00142-0.Peer-Reviewed Original Research
2021
Early events in endothelial flow sensing
Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton 2021, 78: 217-231. PMID: 33543538, DOI: 10.1002/cm.21652.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements