2023
Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins
Morosky P, Comyns C, Nunes L, Chung C, Hoffmann P, Söll D, Vargas-Rodriguez O, Krahn N. Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins. Frontiers In Molecular Biosciences 2023, 10: 1096261. PMID: 36762212, PMCID: PMC9902344, DOI: 10.3389/fmolb.2023.1096261.Peer-Reviewed Original ResearchPost-translational modificationsGenetic code expansionAmino acidsProtein functionCode expansionNon-canonical amino acidsGenetic code expansion techniqueOrthogonal translation systemSkeletal muscle regenerationSelenoprotein functionCell maintenanceBiosynthesis mechanismGenetic systemSelenocysteine insertionPreferred hostMultiple proteinsBiological processesBiology applicationsProtein positionsStop codonCodon sequenceProtein sitesSelenoproteinsChemical biology applicationsMuscle regeneration
2022
Diversification of aminoacyl-tRNA synthetase activities via genomic duplication
Krahn N, Söll D, Vargas-Rodriguez O. Diversification of aminoacyl-tRNA synthetase activities via genomic duplication. Frontiers In Physiology 2022, 13: 983245. PMID: 36060688, PMCID: PMC9437257, DOI: 10.3389/fphys.2022.983245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenomic duplicationSynthetase familyRecent bioinformatic analysisAminoacyl-tRNA synthetase familySynthetic biology applicationsDomains of lifeNew drug targetsAminoacyl-tRNA synthetase activityGene duplicationPhylogenetic diversityEvolutionary eventsGenetic codeBioinformatics analysisImportant bioactive moleculesAdaptive advantageBiological functionsBiological processesBiology applicationsDrug targetsDuplicationAaRSsCatalytic siteSynthetase activityProteinBioactive molecules