2016
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection
Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ. The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. Journal Of Cell Science 2016, 129: 3130-3143. PMID: 27358479, PMCID: PMC5004897, DOI: 10.1242/jcs.185595.Peer-Reviewed Original ResearchMeSH KeywordsAniline CompoundsAnimalsCytokinesDisease Models, AnimalImatinib MesylateImmunoglobulin GLeishmaniaLeishmaniasisMacrophagesMiceModels, BiologicalNitrilesParasitesPhagocytosisPhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-hckPyrimidinesQuinolinesRAW 264.7 CellsSignal TransductionSrc-Family KinasesConceptsAmastigote uptakeObligate intracellular parasite LeishmaniaImmunoglobulin-mediated phagocytosisIntracellular parasite LeishmaniaNovel therapeutic strategiesPersistence of infectionLeishmania infectionIgG-mediated phagocytosisTherapeutic strategiesFc receptorsSmall molecule inhibitorsArg activationDisease severityParasite burdenPrimary macrophagesMacrophagesKinase inhibitorsLeishmaniasisHuman hostDevastating diseaseInfectionParasite LeishmaniaSrc family kinasesPhagocytosisLeishmania
2015
Cutaneous leishmaniasis is regulated by Wnt antagonist Dkk-1 from activated platelets (MPF7P.715)
Bothwell A, Chae W, Ehrlich A, Teixeira A, Goldsmith-Pestana K, Maher S, Hwa J, Krause D, McMahon-Pratt D. Cutaneous leishmaniasis is regulated by Wnt antagonist Dkk-1 from activated platelets (MPF7P.715). The Journal Of Immunology 2015, 194: 203.16-203.16. DOI: 10.4049/jimmunol.194.supp.203.16.Peer-Reviewed Original ResearchNeutrophil-platelet aggregate formationDkk-1Cutaneous leishmaniasisLate inflammatory responseSkin inflammatory diseasesT cell differentiationMajor infectionAntigen exposureLymph nodesChronic inflammationTh2 cytokinesInflammatory diseasesInflammatory responseTh2 cellsSkin lesionsSmall molecule inhibitorsParasite burdenGATA-3Functional inhibitionMarked inhibitionLeishmaniasisC-MafHuman plateletsMolecule inhibitorsPlatelets
2012
The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection
Wetzel DM, McMahon-Pratt D, Koleske AJ. The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection. Molecular And Cellular Biology 2012, 32: 3176-3186. PMID: 22665498, PMCID: PMC3434515, DOI: 10.1128/mcb.00086-12.Peer-Reviewed Original ResearchConceptsComplement receptor 3Leishmania infectionIgG-coated beadsMurine cutaneous leishmaniasisPotential therapeutic targetLeishmania uptakeVisceral diseaseObligate intracellular parasitesCutaneous leishmaniasisTherapeutic targetFc receptorsAmastigote uptakeTreatment resultsReceptor 3Small lesionsInfection severityLeishmania amazonensisKinase inhibitorsIntracellular parasitesBead phagocytosisPhagocytosisReceptorsC3biInfectionLeishmaniasis
2003
Evaluation of amastigote reactive cells in human cutaneous leishmaniasis caused by Leishmania aethiopica
MAASHO K, MCMAHON-PRATT D, RAITA J, RAUD M, BRITTON S, SOONG L, AKUFFO H. Evaluation of amastigote reactive cells in human cutaneous leishmaniasis caused by Leishmania aethiopica. Clinical & Experimental Immunology 2003, 132: 316-322. PMID: 12699423, PMCID: PMC1808716, DOI: 10.1046/j.1365-2249.2003.02165.x.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsCutaneous leishmaniasisNK cellsOld World cutaneous leishmaniasisEthiopian cutaneous leishmaniasisLeishmania parasite infectionIL-10 responsesPercentage of CD4IL-10 productionBlood mononuclear cellsHuman cutaneous leishmaniasisAmastigote antigensLymphoproliferative responsesLeishmaniasis patientsMain cell typesMononuclear cellsAntigen stimulationHuman leishmaniasisGamma interferonLeishmania aethiopicaReactive cellsProtective phenotypePatientsL. aethiopicaLeishmaniasis
2002
Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia.
Saravia NG, Weigle K, Navas C, Segura I, Valderrama L, Valencia AZ, Escorcia B, McMahon-Pratt D. Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia. American Journal Of Tropical Medicine And Hygiene 2002, 66: 738-44. PMID: 12224583, DOI: 10.4269/ajtmh.2002.66.738.Peer-Reviewed Original Research
2001
Biochemical and Biological Characterization of the Protective Leishmania pifanoi Amastigote Antigen P-8
Colmenares M, Tiemeyer M, Kima P, McMahon-Pratt D. Biochemical and Biological Characterization of the Protective Leishmania pifanoi Amastigote Antigen P-8. Infection And Immunity 2001, 69: 6776-6784. PMID: 11598050, PMCID: PMC100055, DOI: 10.1128/iai.69.11.6776-6784.2001.Peer-Reviewed Original ResearchConceptsAntigen PFurther vaccine studiesSignificant T cell activationT cell activationWestern blot analysisProtective immunityVaccine studiesApolipoprotein EMurine modelCutaneous leishmaniasisSignificant protectionComparable protectionImmunodominant componentAntigenic glycolipidsImmunity studiesAntigenCysteine proteinasesGlycolipid componentBiochemical analysisBiological characterizationSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisSulfate-polyacrylamide gel electrophoresisInfectionLeishmaniasis
2000
Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina
Segura E, Juan N, Piquin A, Cuba Cuba C, Abramo Orrego L, McMahon-Pratt D, Montamat E, Momen H, Grimaldi Jr. G. Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina. Parasitology Research 2000, 86: 504-508. PMID: 10894479, DOI: 10.1007/s004360050702.Peer-Reviewed Original ResearchInternalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis
Kima P, Constant S, Hannum L, Colmenares M, Lee K, Haberman A, Shlomchik M, McMahon-Pratt D. Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis. Journal Of Experimental Medicine 2000, 191: 1063-1068. PMID: 10727468, PMCID: PMC2193117, DOI: 10.1084/jem.191.6.1063.Peer-Reviewed Original ResearchConceptsFc receptorsB cell antigen presentationMurine cutaneous leishmaniasisFunctional B cellsCommon gamma chainL. mexicana complexLeishmania infectionAntigen presentationCutaneous leishmaniasisB cellsLeishmania pathogenesisInfectionComplex parasitesCritical roleAntibodiesMexicana complexPathogenesisMiceGamma chainReceptorsParasitesLeishmaniasis
1998
Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite
McMahon-Pratt D, Kima P, Soong L. Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite. Trends In Parasitology 1998, 14: 31-34. PMID: 17040687, DOI: 10.1016/s0169-4758(97)01164-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II presentation pathwayAmastigote stageMHC class ILeishmanial vaccineLeishmanial antigensAntigen presentationT cellsElicit protectionImmunized hostsPresentation pathwayInfected macrophagesMolecular vaccinesVaccine targetsInfected mammalian hostsClass IIntracellular parasitesVaccineInfectionCandidate moleculesMacrophagesMammalian hostsDevelopmental formsImmunizationAntigenLeishmaniasis
1992
Cutaneous Leishmaniasis: Review of 59 Cases Seen at the National Institutes of Health
Melby P, Kreutzer R, McMahon-Pratt D, Gam A, Neva F. Cutaneous Leishmaniasis: Review of 59 Cases Seen at the National Institutes of Health. Clinical Infectious Diseases 1992, 15: 924-937. PMID: 1457663, DOI: 10.1093/clind/15.6.924.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisEndemic areasCutaneous diseaseGroup of patientsDiffuse cutaneous leishmaniasisNational InstituteDifferent endemic areasChronic relapsingFrequent international travelOptimal therapyClinical spectrumMultiple lesionsAmerican patientsLeishmaniasisPatientsLeishmania majorDiseaseLesionsEarly ageInternational travelU.S. residentsHealthRelapsingMajorityTherapy
1991
Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease.
Barral A, Pedral-Sampaio D, Grimaldi G, Momen H, McMahon-Pratt D, de Jesus A, Almeida R, Badaro R, Barral-Netto M, Carvalho E, Johnson W. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. American Journal Of Tropical Medicine And Hygiene 1991, 44: 536-46. PMID: 2063957, DOI: 10.4269/ajtmh.1991.44.536.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisCutaneous leishmaniasisClinical presentationVisceral leishmaniasisCases of CLMonoclonal antibodiesLeishmania amazonensisCases of DCLL. amazonensis infectionDifferent clinical presentationsDifferent clinical formsDifferent Leishmania speciesAmazonensis infectionClinical groundsIndistinguishable clinical presentationDermal leishmaniasisSpecific monoclonal antibodiesClinical formsClinical diseaseLeishmanial diseaseL. chagasiWide spectrumLeishmania referenceLeishmaniasisL. amazonensisLeishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras
Ponce C, Ponce E, Morrison A, Cruz A, Kreutzer R, McMahon-Pratt D, Neva F. Leishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras. The Lancet 1991, 337: 67-70. PMID: 1670724, DOI: 10.1016/0140-6736(91)90734-7.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisSkin lesionsEndemic visceral leishmaniasisMontenegro skin testNew clinical variantAtypical cutaneous leishmaniasisSkin testLaboratory criteriaClinical variantsVisceral leishmaniasisKala-azarBone marrowPatientsParasite isolatesLesionsMajor antigenLeishmaniasisLeishmania mexicanaUnusual formIsoenzyme analysisYearsMarrowAntigenChagasiMonths
1988
Purification and characterization of an 80-kilodalton membrane protein from Leishmania donovani
White A, McMahon-Pratt D. Purification and characterization of an 80-kilodalton membrane protein from Leishmania donovani. Infection And Immunity 1988, 56: 2385-2391. PMID: 3165961, PMCID: PMC259577, DOI: 10.1128/iai.56.9.2385-2391.1988.Peer-Reviewed Original ResearchBiology of Leishmania and Leishmaniasis
Furtado T, Goihman-Yahr M, Marghescu S, Grimaldi G, David J, McMahon-Pratt D, Rothenberg A, Rosquete R, Avila-Millán E, Istúriz G, Viloria N, de Borges N, Carrasquero M, de Fernández B, Tapia F, de Albornoz M, Bretaña A, de Brito I, Urquiola G, Pereira J, Martín B, de Gómez M, de Román A, Lugo A, Convit J, Padilha-Gonçalves A, Vale E, Araújo M. Biology of Leishmania and Leishmaniasis. 1988, 782-800. DOI: 10.1007/978-3-642-83360-1_87.Commentaries, Editorials and LettersDifferent clinical manifestationsImmunological characterizationCulture of parasitesBiology of LeishmaniaClinical manifestationsReference centerInternational Reference CentreL. tropicaMonoclonal antibodiesParasite strainsElectron microscopic morphologyNew World LeishmaniaLeishmaniaIsoenzyme patternsBraziliensisDonovaniBiochemical methodsParasitesLeishmaniasisDisease
1987
Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies
Jaffe C, McMahon-Pratt D. Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1987, 81: 587-594. PMID: 3445339, DOI: 10.1016/0035-9203(87)90418-4.Peer-Reviewed Original ResearchConceptsVisceral leishmaniasisMonoclonal antibodiesSerodiagnostic assaysVL seraParasite antigensChagas diseaseSystemic lupus erythematosusNon-endemic areasDifferent parasite antigensLeishmania antigenLupus erythematosusMucocutaneous leishmaniasisLepromatous leprosyNegative control seraPositive casesSpecies-specific monoclonal antibodiesNormal serumControl seraRapid diagnosisAntigenSerum dilutionSerumAntibodiesLeishmaniasisSpecific inhibition
1985
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity.
Saravia N, Holguín A, D'Alessandro A, McMahon-Pratt D. Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. American Journal Of Tropical Medicine And Hygiene 1985, 34: 714-20. PMID: 4025684, DOI: 10.4269/ajtmh.1985.34.714.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisLeishmania braziliensis braziliensisCutaneous manifestationsMucocutaneous diseaseMucocutaneous lesionsMucosal lesionsMetastatic developmentDisease formsEtiologic agentLeishmania braziliensisLeishmania isolatesLeishmaniasisLesionsBraziliensisSpecificity characteristicsParasitesPatientsDisease
1984
Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis.
Jaffe C, Bennett E, Grimaldi G, McMahon-Pratt D. Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis. The Journal Of Immunology 1984, 133: 440-7. PMID: 6373932, DOI: 10.4049/jimmunol.133.1.440.Peer-Reviewed Original ResearchConceptsMonoclonal antibodiesVisceral leishmaniasisSpecies-specific monoclonal antibodiesL. donovaniAntibody DAntigenic determinantsLeishmania donovaniKala-azar serumWestern blot analysisSpecies of LeishmaniaSerologic assaysEpidemiologic studiesClinical diagnosisWestern blotAntigenic moleculesProtein antigensRadioimmunoprecipitation analysisAntibodiesLeishmaniasisLeishmania speciesLeishmania stocksDonovaniMonoclonal antibody DBlot analysisAntigen