2011
The antihyperalgesic effect of cytidine-5′-diphosphate-choline in neuropathic and inflammatory pain models
Bagdas D, Sonat F, Hamurtekin E, Sonal S, Gurun M. The antihyperalgesic effect of cytidine-5′-diphosphate-choline in neuropathic and inflammatory pain models. Behavioural Pharmacology 2011, 22: 589-598. PMID: 21836465, DOI: 10.1097/fbp.0b013e32834a1efb.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelAntihyperalgesic effectPain modelChronic constriction injury-induced neuropathic pain modelNonselective muscarinic receptor antagonist atropineNonselective opioid receptor antagonist naloxoneΓ-aminobutyric acid B receptorsNicotinic ACh receptor antagonistsReceptor antagonist CGP 35348Muscarinic receptor antagonist atropineNicotinic receptor antagonist mecamylamineOpioid receptor antagonist naloxoneCholine uptake inhibitor hemicholinium-3CDP-cholineEffect of intracerebroventricularlyAntagonist CGP 35348Central opioid receptorsInflammatory pain modelACh receptor antagonistNicotinic ACh receptorsCGP 35348Mechanical hyperalgesiaNeuropathic painAntagonist atropineAntagonist naloxone
2007
Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats
Hamurtekin E, Bagdas D, Gurun M. Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. Neuroscience Letters 2007, 420: 116-121. PMID: 17531379, DOI: 10.1016/j.neulet.2007.04.058.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdrenergic alpha-AntagonistsAnalgesicsAnimalsBrainCytidine Diphosphate CholineDisease Models, AnimalEfferent PathwaysGABA AntagonistsInjections, IntraventricularMaleNarcotic AntagonistsNociceptorsPainPain MeasurementPain ThresholdRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReceptors, GABAReceptors, GABA-BReceptors, OpioidReceptors, SerotoninSerotonin AntagonistsConceptsAcute pain modelsMechanical paw pressure testThermal paw withdrawal testPaw pressure testPaw withdrawal testAntinociceptive effectPain modelSupraspinal opioidsSerotonergic receptorsAlpha-1 adrenergic receptor antagonist prazosinCDP-cholineWithdrawal testOpioid receptor antagonist naloxoneAdrenergic receptor antagonist prazosinAdrenergic receptor antagonist yohimbineCytidine-5′-diphosphate cholineDifferent pain modelsExerts antinociceptive effectsDose-dependent antinociceptionReceptor antagonist yohimbineReceptor antagonist prazosinReceptor-mediated mechanismMethysergide pretreatmentAntagonist yohimbineAntagonist prazosin