2019
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
Bryant C, Bagdas D, Goldberg L, Khalefa T, Reed E, Kirkpatrick S, Kelliher J, Chen M, Johnson W, Mulligan M, Damaj M. C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception. Molecular Pain 2019, 15: 1744806918825046. PMID: 30632432, PMCID: PMC6365993, DOI: 10.1177/1744806918825046.Peer-Reviewed Original ResearchConceptsAcute thermal nociceptionThermal nociceptionNerve injuryNociceptive behaviorPain modalitiesB6N miceAdjuvant modelComplete Freund's adjuvant (CFA) modelChronic constrictive nerve injuryBaseline mechanical thresholdInflammatory nociceptive behaviorsInflammatory nociceptive stimulusStrain differencesFreund's adjuvant modelDifferent pain modalitiesHot plate testPreclinical pain modelsHot plate sensitivityNeuropathic nociceptionNociceptive markersPaw diameterMechanical hypersensitivityInflammatory painNeuropathic painPain model
2014
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
Papke R, Bagdas D, Kulkarni A, Gould T, AlSharari S, Thakur G, Damaj M. The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 2014, 91: 34-42. PMID: 25497451, PMCID: PMC4312719, DOI: 10.1016/j.neuropharm.2014.12.002.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsChronic painAntinociceptive activityΑ7 nicotinic acetylcholine receptorAnalgesic-like propertiesPain-induced aversionNerve injury modelAcute thermal painNon-neuronal cellsNicotinic acetylcholine receptorsImportant affective componentIon channelsNeuropathic painPain modelNociceptive behaviorInflammatory diseasesInjury modelNS6740Α7 nAChRsΑ7 receptorsThermal painPainAcetylcholine receptorsChannel activatorNeurological disorders
2013
Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain
Bagdas D, Yucel-Ozboluk H, Orhan F, Kanat O, Isbil-Buyukcoskun N, Gurun M. Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain. Neuroreport 2013, 24: 941-946. PMID: 24089014, DOI: 10.1097/wnr.0000000000000009.Peer-Reviewed Original ResearchConceptsCentral AVP receptorsAnalgesic effectAVP V1Pain modelAVP receptorsChronic constriction injury-induced neuropathic pain modelCDP-cholineDifferent pain modelsRandall-Selitto testNeuropathic pain modelAVP V2 receptorsV2 receptor antagonistAVP V2 receptor antagonistArginine vasopressin receptorsNeuropathic painNeuropathic modelsPain modulationIntracerebroventricular injectionPain thresholdReceptor antagonistVasopressin levelsV2 receptorsVasopressin receptorsRatsReceptorsPreclinical evidence for the antihyperalgesic activity of CDP-choline in oxaliplatin-induced neuropathic pain.
Kanat O, Bagdas D, Ozboluk H, Gurun M. Preclinical evidence for the antihyperalgesic activity of CDP-choline in oxaliplatin-induced neuropathic pain. JBUON 2013, 18: 1012-8. PMID: 24344031.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnimalsCytidine Diphosphate CholineDisease Models, AnimalDose-Response Relationship, DrugGABA-B Receptor AntagonistsHyperalgesiaInjections, IntraventricularMaleNeuralgiaNeurotransmitter Uptake InhibitorsNicotinic AntagonistsOrganoplatinum CompoundsOxaliplatinPain ThresholdRatsRats, Sprague-DawleyTime FactorsConceptsAntihyperalgesic effectNeuropathic painCDP-cholineNonselective muscarinic receptor antagonist atropineNonselective opioid receptor antagonist naloxoneRat paw pressure testReceptor antagonist CGP 35348Muscarinic receptor antagonist atropineNicotinic receptor antagonist mecamylamineOpioid receptor antagonist naloxoneOxaliplatin-induced neuropathic painCholine uptake inhibitor hemicholinium-3Induction of neuropathyAntagonist CGP 35348Paw pressure testGamma-amino butyric acidNicotinic acetylcholine receptorsCGP 35348Neuropatic painMechanical hyperalgesiaAntagonist atropineTime-dependent mannerPreclinical evidenceAntagonist naloxoneAntihyperalgesic activity
2007
Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats
Hamurtekin E, Bagdas D, Gurun M. Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. Neuroscience Letters 2007, 420: 116-121. PMID: 17531379, DOI: 10.1016/j.neulet.2007.04.058.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdrenergic alpha-AntagonistsAnalgesicsAnimalsBrainCytidine Diphosphate CholineDisease Models, AnimalEfferent PathwaysGABA AntagonistsInjections, IntraventricularMaleNarcotic AntagonistsNociceptorsPainPain MeasurementPain ThresholdRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReceptors, GABAReceptors, GABA-BReceptors, OpioidReceptors, SerotoninSerotonin AntagonistsConceptsAcute pain modelsMechanical paw pressure testThermal paw withdrawal testPaw pressure testPaw withdrawal testAntinociceptive effectPain modelSupraspinal opioidsSerotonergic receptorsAlpha-1 adrenergic receptor antagonist prazosinCDP-cholineWithdrawal testOpioid receptor antagonist naloxoneAdrenergic receptor antagonist prazosinAdrenergic receptor antagonist yohimbineCytidine-5′-diphosphate cholineDifferent pain modelsExerts antinociceptive effectsDose-dependent antinociceptionReceptor antagonist yohimbineReceptor antagonist prazosinReceptor-mediated mechanismMethysergide pretreatmentAntagonist yohimbineAntagonist prazosin