Featured Publications
In Vitro Gametogenesis in Oncofertility: A Review of Its Potential Use and Present-Day Challenges in Moving toward Fertility Preservation and Restoration
Wesevich V, Arkfeld C, Seifer D. In Vitro Gametogenesis in Oncofertility: A Review of Its Potential Use and Present-Day Challenges in Moving toward Fertility Preservation and Restoration. Journal Of Clinical Medicine 2023, 12: 3305. PMID: 37176745, PMCID: PMC10179531, DOI: 10.3390/jcm12093305.Peer-Reviewed Original ResearchPluripotent stem cellsPrimordial germ cell-like cellsGerm cell-like cellsStem cell biology researchStem cellsCell biology researchCell-like cellsVitro gametogenesisBiology researchReproductive lifespanGametogenesisFibroblast cellsDermal fibroblast cellsCellsReprogrammingEmbryogenesisOogoniaEmbryosViable oocytesFertilityReproductionSpermatocytesCurrent fertility preservation optionsOocytesEx vivo
2002
Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization
Seifer DB, DeJesus V, Hubbard K. Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization. Fertility And Sterility 2002, 78: 1046-1048. PMID: 12413991, DOI: 10.1016/s0015-0282(02)04214-0.Peer-Reviewed Original ResearchConceptsGranulosa cellsAdvanced reproductive ageLuteinized granulosa cellsMitochondrial DNA deletionsGonadotropin stimulationReproductive ageMAIN OUTCOMEFollicular aspirationFertility clinicsFunction of ageYoung womenWomenIVFAgeDNA deletionsCellsMitochondrial deletionsYearsNormal mitochondriaNormal mtDNAPatientsDeletionClinicSubstantial decreaseDNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve
Chin KV, Seifer DB, Feng B, Lin Y, Shih WC. DNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve. Fertility And Sterility 2002, 77: 1214-1218. PMID: 12057731, DOI: 10.1016/s0015-0282(02)03114-x.Peer-Reviewed Original ResearchConceptsLuteinized granulosa cellsOvarian reserveDNA microarray analysisGranulosa cellsExpression profilesMicroarray analysisSequence tagsFertilization-embryo transferUniversity-based fertility clinicExpression profilingComplementary DNA microarray analysisGonadotropin stimulationFollicular aspirationMAIN OUTCOMEFertility clinicsWomenDNA microarraysGene expressionCellsGenesProfilingPatientsIVFClinicSignature patterns
1996
Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†
Seifer D, Gardiner A, Ferreira K, Peluso J. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†. Fertility And Sterility 1996, 66: 593-598. PMID: 8816622, DOI: 10.1016/s0015-0282(16)58573-2.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHFSH levelsOvarian reserveSerum FSHMIU/Granulosa cellsCell countDiminished ovarian reserveMIU/mLAcademic clinical practiceLuteinized granulosa cellsApoptotic granulosa cellsIVF-ETFollicular aspiratesPreovulatory folliclesClinical practiceFlow cytometryWomenMean numberApoptotic cellsFSHGreater percentageFolliclesCellsViable cellsA Combined Cytogenetic and Molecular Approach for Diagnosing Delayed Puberty
Hon Fong Louie Mark, Bayleran J, Seifer D, Meyers-Seifer C. A Combined Cytogenetic and Molecular Approach for Diagnosing Delayed Puberty. Clinical Pediatrics 1996, 35: 62-66. PMID: 8775477, DOI: 10.1177/000992289603500202.Peer-Reviewed Original ResearchConceptsLaparoscopic bilateral gonadectomyRisk of neoplasiaPeripheral blood leukocytesCell linesBilateral gonadectomyPolymerase chain reactionIntact short armsBlood leukocytesDelayed pubertyConventional cytogenetic studiesSubpopulation of cellsShort statureY chromosome materialChromosomal analysisChain reactionPubertyPhenotypic femalesCytogenetic studiesPresent reportCombined CytogeneticSitu hybridizationMolecular analysisUnequivocal evidenceCells
1991
The Neuroendocrine Regulation of the Menstrual Cycle
Meyers-Seifer C, Seifer D. The Neuroendocrine Regulation of the Menstrual Cycle. Clinical Perspectives In Obstetrics And Gynecology 1991, 1-21. DOI: 10.1007/978-1-4612-3026-7_1.Peer-Reviewed Original Research