2002
Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization
Seifer DB, DeJesus V, Hubbard K. Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization. Fertility And Sterility 2002, 78: 1046-1048. PMID: 12413991, DOI: 10.1016/s0015-0282(02)04214-0.Peer-Reviewed Original ResearchConceptsGranulosa cellsAdvanced reproductive ageLuteinized granulosa cellsMitochondrial DNA deletionsGonadotropin stimulationReproductive ageMAIN OUTCOMEFollicular aspirationFertility clinicsFunction of ageYoung womenWomenIVFAgeDNA deletionsCellsMitochondrial deletionsYearsNormal mitochondriaNormal mtDNAPatientsDeletionClinicSubstantial decrease
1997
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction
Friedman C, Danforth D, Herbosa-Encarnacion C, Arbogast L, Alak B, Seifer D. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertility And Sterility 1997, 68: 607-612. PMID: 9341598, DOI: 10.1016/s0015-0282(97)00278-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCobaltCohort StudiesCorpus LuteumEndothelial Growth FactorsFemaleFollicular FluidGranulosa CellsHumansHypoxiaLymphokinesMaternal AgeMiddle AgedOsmolar ConcentrationOvulation InductionPregnancyPregnancy, High-RiskRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAdvanced reproductive ageVascular endothelial growth factor/vascular permeability factorVascular permeability factorReproductive ageFollicular fluidFactor concentrationsPermeability factorFollicular fluid vascular endothelial growth factor concentrationsGranulosa cellsVascular endothelial growth factor concentrationsYoung womenRetrospective cohort studyReproductive-age womenUniversity Teaching HospitalPg/mLGrowth factor concentrationsCohort studyIVF-ETOvulation inductionHCG administrationAge womenCobalt chlorideTeaching hospitalMAIN OUTCOMEFollicular aspiration
1993
Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve
Seifer D, Charland C, Berlinsky D, Penzias A, Haning R, Naftolin F, Barker B. Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve. American Journal Of Obstetrics And Gynecology 1993, 169: 1531-1535. PMID: 8267057, DOI: 10.1016/0002-9378(93)90430-q.Peer-Reviewed Original ResearchConceptsSerum follicle-stimulating hormone levelsFollicle-stimulating hormone levelsFollicle-stimulating hormoneLuteinized granulosa cellsIU/L.Ovarian reserveHormone levelsProliferative indexGranulosa cellsHormone groupChronologic agePreovulatory folliclesDay 3 follicle-stimulating hormone levelsHigh follicle-stimulating hormoneLower follicle-stimulating hormoneSerum follicle-stimulating hormoneFlow cytometryHuman luteinized granulosa cellsGreater proliferative indexSame chronologic ageWoman's ovarian reserveOvulation induction protocolsProspective cohort studyAdvanced reproductive ageIU/L