2020
Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
2004
New preservation solutions for use in liver transplantation
Mulligan D, Reddy K, Moss A. New preservation solutions for use in liver transplantation. Current Opinion In Organ Transplantation 2004, 9: 159-162. DOI: 10.1097/01.mot.0000127629.78517.06.Peer-Reviewed Original ResearchNew preservation solutionLiver transplantationPreservation solutionDonor liversClinical studiesEnd-stage liver diseasePartial liver graftsMainstay of treatmentOrgan preservation solutionsLiver graftsReperfusion injuryLiver diseaseMarginal organsWaiting listWisconsin solutionTransplantationExperimental modelContinuous perfusionIdentification of pathwaysLiverRecent findingsIschemiaNovel advancesCelsiorGraft