2002
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
1998
Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIH
1995
Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors
Lee K, McCormick D. Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors. Journal Of Neurophysiology 1995, 73: 2123-2128. PMID: 7623105, DOI: 10.1152/jn.1995.73.5.2123.Peer-Reviewed Original ResearchConceptsAction of acetylcholineSingle spike activityPerigeniculate nucleusPGN cellsGABAergic neuronsSpike activityLocal applicationDirect postsynaptic actionFerret thalamic slicesNicotinic antagonist hexamethoniumIntracellular recording techniquesAction potential firingLow-threshold Ca2Slow hyperpolarizing responseVitro. 2Antagonist hexamethoniumMembrane conductancePostsynaptic actionsGABAergic cellsMuscarinic antagonistMuscarinic receptorsDepolarizing responsePGN neuronsHyperpolarizing responseSynaptic transmissionSynaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide
1994
From Cellular to Network Mechanisms of a Thalamic Synchronized Oscillation
Bal T, von Krosigk M, McCormick D. From Cellular to Network Mechanisms of a Thalamic Synchronized Oscillation. Research And Perspectives In Neurosciences 1994, 129-143. DOI: 10.1007/978-3-642-85148-3_8.Peer-Reviewed Original ResearchSpindle wavesDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusIntracellular recording techniquesLateral geniculate nucleusGeneralized epilepsyAbsence seizuresGABAA receptorsSlice preparationGeniculate nucleusPharmacological blockSynaptic networksNeural circuitsRecording techniquesCortical systemsPhysiological basisIonic conductancesEpilepsySeizuresLGNdSynchronized oscillations
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slicesAcetylcholine causes rapid nicotinic excitation in the medial habenular nucleus of guinea pig, in vitro
McCormick D, Prince D. Acetylcholine causes rapid nicotinic excitation in the medial habenular nucleus of guinea pig, in vitro. Journal Of Neuroscience 1987, 7: 742-752. PMID: 3549993, PMCID: PMC6569057, DOI: 10.1523/jneurosci.07-03-00742.1987.Peer-Reviewed Original ResearchConceptsMedial habenular nucleusInhibitory responsesMHb neuronsNicotinic receptorsHabenular nucleusACh-induced depolarizationMuscarinic antagonist atropineNicotinic antagonist hexamethoniumIntracellular recording techniquesEffects of AChAction of AChApplication of AChNicotinic agonist nicotineApplication of glutamateAverage reversal potentialNicotinic excitationNicotinic typePostexcitatory inhibitionAntagonist atropineAntagonist hexamethoniumMembrane conductanceACh actionACh responseCentral effectsCholinergic transmission
1985
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick D, Connors B, Lighthall J, Prince D. Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. Journal Of Neurophysiology 1985, 54: 782-806. PMID: 2999347, DOI: 10.1152/jn.1985.54.4.782.Peer-Reviewed Original ResearchConceptsRegular-spiking cellsAction potentialsSpiny stellate neuronsIntracellular recording techniquesAnterior cingulate areaDistinct neuronal classesAnterior cingulate cortexProminent afterhyperpolarizationTonic currentsStellate neuronsMean durationTrain of spikesCingulate areasFluorescent dye Lucifer Yellow CHDye Lucifer Yellow CHSynaptic pathwaysIntracellular injectionSpike frequencyCingulate cortexFast spikingSpike riseElectrophysiological propertiesNeuronal classesGuinea pigsComparative electrophysiology