1998
Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIHPeriodicity of Thalamic Synchronized Oscillations: the Role of Ca2+-Mediated Upregulation of Ih
Lüthi A, McCormick D. Periodicity of Thalamic Synchronized Oscillations: the Role of Ca2+-Mediated Upregulation of Ih. Neuron 1998, 20: 553-563. PMID: 9539128, DOI: 10.1016/s0896-6273(00)80994-0.Peer-Reviewed Original ResearchConceptsPersistent activationRefractory periodHyperpolarization-activated cation current IhNeural network oscillationsSynchronized network activityWave seizuresRole of Ca2Synchronized dischargesThalamocortical cellsThalamocortical networkElectrophysiological propertiesMediated UpregulationSpindle wavesCurrent IhConstituent neuronsNetwork oscillationsAbnormal patternsActivation curveTime courseNetwork activityUpregulationActivationCritical determinant
1996
Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro
Lee K, McCormick D. Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro. Neuron 1996, 17: 309-321. PMID: 8780654, DOI: 10.1016/s0896-6273(00)80162-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationThalamocortical neuronsSpindle wavesPerigeniculate nucleusLocal applicationDorsal lateral geniculate nucleusHyperpolarization-activated cation current IhModulation of IhLateral geniculate nucleusBeta-adrenergic agonistsAdenylyl cyclase activatorGABAergic cellsLateral geniculateChannel blockersGeniculate nucleusNorepinephrineLamina A1Current IhNeuronsSpindle oscillationsCyclase activatorSerotoninIHBlockersAgonists
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance