2003
Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret
Monckton J, McCormick D. Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret. Thalamus & Related Systems 2003, 2: 239-252. DOI: 10.1016/s1472-9288(03)00022-0.Peer-Reviewed Original ResearchApplication of serotoninThalamocortical neuronsLow-threshold Ca2Pulvinar neuronsThreshold Ca2Hyperpolarization-activated cation currentSingle spike activityBasic electrophysiological propertiesDistinct firing modesProminent hyperpolarizationMembrane potassium conductanceSerotoninergic propertiesSignificant species-dependent differencesSpike activityCation currentMonkey neuronsElectrophysiological propertiesPotassium conductanceNeuronsPharmacological propertiesSerotoninMonkeysCatsPulvinarSpecies-dependent differences
1999
Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulation
1992
Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators
MCCORMICK D, STROWBRIDGE B, HUGUENARD J. Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators. 1992, 259-290. DOI: 10.1016/b978-0-12-484815-3.50017-7.Peer-Reviewed Original ResearchState-dependent processingRelay neuronsSingle neuron propertiesHyperpolarization-activated cation currentNeuron propertiesThalamic relay neuronsAction potential generationThalamic neuronsCentral neuronsRhythmic burstsNervous systemCation currentSynaptic connectionsPacemaker currentThalamusNeuronsMotor informationPotential generationNeuromodulatorsFunctional consequences
1989
Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMP