2024
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning
Martin K, Papadoyannis E, Schiavo J, Fadaei S, Issa H, Song S, Valencia S, Temiz N, McGinley M, McCormick D, Froemke R. Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning. Nature Neuroscience 2024, 27: 2152-2166. PMID: 39284963, DOI: 10.1038/s41593-024-01767-4.Peer-Reviewed Original ResearchVagus nerve stimulationCentral cholinergic systemNerve stimulationEfficacy of vagus nerve stimulationCholinergic systemVagus nerve stimulation electrodesExperience-dependent plasticityAuditory cortical responsesPeripheral nerve stimulationCholinergic modulationAuditory discrimination taskClinical conditionsTwo-photon imagingCortical responsesCentral mechanismsCholinergic axonsStimulationEnhance task performanceNeural activityOptogenetic experimentsDiscrimination taskDiscrimination abilityEnhances perceptual learningPerceptual learningTask performance
1988
Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus
McCormick D, Pape H. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988, 334: 246-248. PMID: 3398922, DOI: 10.1038/334246a0.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusRelay cellsGeniculate nucleusDorsal lateral geniculate nucleusMuscarinic receptor-mediated increaseBrainstem cholinergic neuronsCat lateral geniculate nucleusInhibitory postsynaptic potentialsReceptor-mediated increaseDistinctive electrophysiological propertiesUnderlying ionic mechanismsLGNd relay cellsAcetylcholine inhibitsCholinergic neuronsAcetylcholine releaseCerebral cortexCholinergic actionCholinergic axonsPostsynaptic potentialsRelay neuronsCholinergic systemFacilitatory influenceElectrophysiological propertiesCat LGNdIntrageniculate interneurons