2012
Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma
Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-643. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBlotting, WesternCell Line, TumorDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHodgkin DiseaseHumansImmunohistochemistryLymphoma, FollicularMaleMiddle AgedPolymerase Chain ReactionReed-Sternberg CellsRoseolovirus InfectionsSclerosisYoung AdultConceptsNodular sclerosis Hodgkin lymphomaNodular sclerosis HLHHV-6 DNAEpstein-Barr virusHHV-6Hodgkin's lymphomaReed-Sternberg cellsPolymerase chain reactionRS cellsNSHL casesEBV-negative diseaseReactive lymphoid hyperplasiaClassical Hodgkin lymphomaBi-modal age distributionHHV-6 genomeYounger patientsInfectious etiologyLymphoid hyperplasiaPCR positivityYounger ageImmunohistochemistryMost casesConflicting resultsChain reactionCD30
2006
Anatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2005
Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils
Hudnall SD, Ge Y, Wei L, Yang NP, Wang HQ, Chen T. Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils. Modern Pathology 2005, 18: 519-527. PMID: 15696119, DOI: 10.1038/modpathol.3800369.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesChildChild, PreschoolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPalatine TonsilT-LymphocytesViral Matrix ProteinsViral ProteinsConceptsEpstein-Barr virusEBER-positive cellsT cellsHuman tonsilsNK cellsPlasma cellsEpithelial cellsB cellsBiology of EBVNK/T-cell lymphomaEpstein-Barr virus-infected cellsEBV latent protein EBNA1CD20-positive B cellsCD3-positive T cellsEarly Protein BZLF1Non-B cell typeNatural killer cellsRare T cellsT-cell lymphomaLMP1-positive cellsVirus-infected cellsMost tonsilsPlasmacytoid morphologyKiller cellsInterfollicular zones
2004
Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis
Ventura KC, Hudnall SD. Hematologic differences in heterophile‐positive and heterophile‐negative infectious mononucleosis. American Journal Of Hematology 2004, 76: 315-318. PMID: 15282662, DOI: 10.1002/ajh.20119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAnimalsAntibodies, HeterophileCattleChildChild, PreschoolCross ReactionsFemaleHerpesvirus 4, HumanHumansInfectious MononucleosisLatex Fixation TestsLeukocyte CountLeukopeniaLymphocyte CountLymphocytesLymphocytosisMaleMiddle AgedRetrospective StudiesConceptsEBV-positive patientsEBV-negative patientsAbsolute lymphocyte countInfectious mononucleosisAtypical lymphocytosisLymphocyte countEpstein-Barr virus infectionEBV-negative casesEBV-negative groupTotal WBC countAgglutination test resultsAtypical lymphocytesAbsolute lymphocytosisBlood countLeukocyte countWBC countHematologic parametersVirus infectionMononucleosisHematologic differencesPatientsLymphocytosisEBVCountCauseSpecies identification of all eight human herpesviruses with a single nested PCR assay
Hudnall SD, Chen T, Tyring SK. Species identification of all eight human herpesviruses with a single nested PCR assay. Journal Of Virological Methods 2004, 116: 19-26. PMID: 14715303, DOI: 10.1016/j.jviromet.2003.10.005.Peer-Reviewed Original ResearchMeSH KeywordsCytomegalovirusDNA PrimersDNA-Directed DNA PolymeraseElectrophoretic Mobility Shift AssayHerpesviridaeHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHeteroduplex AnalysisHumansNucleic Acid HybridizationPolymerase Chain ReactionConceptsHuman herpesvirusesPolymerase chain reactionHHV-6 subtypesClinical materialSignificant morbidityViral culturePrimary infectionLatent persistenceMultiple herpesvirusesChemiluminescent dot blot hybridizationChain reactionHeteroduplex mobilityHuman hostHerpesvirus detectionDot blot hybridizationHerpesvirusHerpesvirus DNA polymerase gene
2001
Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo
Walling D, Flaitz C, Nichols C, Hudnall S, Adler-Storthz K. Persistent Productive Epstein-Barr Virus Replication in Normal Epithelial Cells In Vivo. The Journal Of Infectious Diseases 2001, 184: 1499-1507. PMID: 11740724, DOI: 10.1086/323992.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusEpstein-Barr virus replicationHairy leukoplakiaEBV replicationValacyclovir treatmentVirus replicationNormal tongue tissuesPersistent EBV infectionProductive EBV replicationReverse transcriptase-polymerase chain reaction amplificationOral hairy leukoplakiaEpithelial cellsOral epithelial lesionsTongue epithelial cellsEBV infectionNormal epithelial cellsEBV DNAImmunodeficiency virusBiopsy specimensEpithelial lesionsImmunohistochemical detectionLeukoplakiaPolymerase chain reaction amplificationTongue tissueChain reaction amplification
2000
Kikuchi-Fujimoto Disease
Hudnall S. Kikuchi-Fujimoto Disease. American Journal Of Clinical Pathology 2000, 113: 761-764. PMID: 10874874, DOI: 10.1309/n4e2-78v9-qtfh-x4ff.Peer-Reviewed Original Research
1997
EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations
Yen A, Fearneyhough P, Raimer S, Hudnall S. EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. Journal Of The American Academy Of Dermatology 1997, 36: 342-346. PMID: 9039215, DOI: 10.1016/s0190-9622(97)80413-6.Peer-Reviewed Original ResearchConceptsHistiocytic necrotizing lymphadenitisKikuchi's histiocytic necrotizing lymphadenitisNecrotizing lymphadenitisCutaneous manifestationsSkin lesionsAtypical lymphoid cellsEBER-1 RNACrusted papulesLymph nodesMalignant lymphomaPathologic findingsKaryorrhectic debrisSerologic studiesPatchy necrosisHistiocytic aggregatesSpontaneous resolutionImmunoperoxidase stainingLymphoid cellsLymphadenitisCausative agentLesionsEBVSitu hybridizationManifestationsMyalgia
1994
Multiple myeloma after cardiac transplantation: An unusual form of posttransplant lymphoproliferative disorder
Chucrallah A, Crow M, Rice L, Rajagopalan S, Hudnall S. Multiple myeloma after cardiac transplantation: An unusual form of posttransplant lymphoproliferative disorder. Human Pathology 1994, 25: 541-545. PMID: 8200651, DOI: 10.1016/0046-8177(94)90129-5.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, ViralBase SequenceDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensGene RearrangementGenes, ImmunoglobulinHeart TransplantationHerpesvirus 4, HumanHumansIn Situ HybridizationLymphoproliferative DisordersMaleMiddle AgedMolecular Sequence DataMultiple MyelomaPolymerase Chain ReactionRNA, ViralConceptsPosttransplant lymphoproliferative disorderPolymerase chain reactionCardiac transplantationLymphoproliferative disordersMonoclonal immunoglobulin heavy chain gene rearrangementEBV-negative casesPast EBV infectionCardiac transplant recipientsImmature plasma cellsImmunoglobulin heavy chain gene rearrangementHeavy chain gene rearrangementChain gene rearrangementCyclosporin withdrawalEBV infectionTransplant recipientsEBER-1Monomorphous populationMultiple myelomaEBV genomePlasma cellsSkull lesionsMyelomaSerum analysisGene rearrangementsChain reaction
1991
Cyclosporin A renders target cells resistant to immune cytolysis
Hudnall S. Cyclosporin A renders target cells resistant to immune cytolysis. European Journal Of Immunology 1991, 21: 221-226. PMID: 1846819, DOI: 10.1002/eji.1830210133.Peer-Reviewed Original ResearchConceptsCsA dose reductionB-cell hyperplasiaB lymphocytesDose reductionCell growth inhibitionNatural killerCell hyperplasiaEarly post-transplant lymphoproliferative disordersHuman organ transplant recipientsPost-transplant lymphoproliferative disorderT cell-dependent responsesAntibody-dependent responsesPost-transplant settingOrgan transplant recipientsTarget cellsEpstein-Barr virusCell-dependent responsesHuman target cellsComplement-mediated cytolysisGrowth inhibitionTransplant recipientsDisease regressionImmune controlNK cellsLymphoproliferative disorders
1987
B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus
Garcia C, Brown N, Schreck R, Stiehm E, Hudnall S. B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus. Cancer 1987, 60: 2941-2947. PMID: 2824020, DOI: 10.1002/1097-0142(19871215)60:12<2941::aid-cncr2820601216>3.0.co;2-a.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesFemaleHerpesvirus 4, HumanHumansImmunologic Deficiency SyndromesInfantLymphomaConceptsEpstein-Barr virus nuclear antigenB-cell lymphomaB-cell lymphoproliferative disordersEBV DNASevere combined immunodeficiencyLymphoproliferative disordersMalignant B-cell lymphomaEBV DNA probePrevention of EBVImmunoglobulin heavy chain gene rearrangementB-cell lymphoproliferationEpstein-Barr virusClonal B-cell lymphomaGene rearrangementsHeavy chain gene rearrangementClonal Ig gene rearrangementsChain gene rearrangementAntiviral chemoprophylaxisTransplant patientsSuch prophylaxisImmunodeficient patientsTumor cell DNAAnticomplement immunofluorescenceSitu cytohybridizationPatients