2020
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J
Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J. EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.Peer-Reviewed Original ResearchDose-limiting organUrinary bladderTime-activity curvesSynaptic densityOLINDA/EXM 1.0 softwareWhole-body PET scansWhole-body scanHuman adultsDose limitTotal radiation doseGastrointestinal tractPET scansHealthy adultsInjected activityRegion of interestLarge intestineNeuropsychiatric disordersEffective doseRelevant disordersBladderLiverRadiation doseAdultsMBqHigh uptake
2014
In Vivo Evaluation of 18F-MNI698: An 18F-Labeled Radiotracer for Imaging of Serotonin 4 Receptors in Brain
Tavares AA, Caillé F, Barret O, Papin C, Lee H, Morley TJ, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD. In Vivo Evaluation of 18F-MNI698: An 18F-Labeled Radiotracer for Imaging of Serotonin 4 Receptors in Brain. Journal Of Nuclear Medicine 2014, 55: 858-864. PMID: 24686782, DOI: 10.2967/jnumed.113.132712.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingDioxanesDose-Response Relationship, RadiationFemaleFluorine RadioisotopesImage Processing, Computer-AssistedKineticsMacaca mulattaMalePiperidinesPositron-Emission TomographyRadiopharmaceuticalsReceptors, Serotonin, 5-HT4Reproducibility of ResultsSerotonin AntagonistsTime FactorsTissue DistributionConceptsBrain disordersPET radiotracersSerotonin 4 receptorBolus intravenous injectionNovel therapeutic approachesMultiple brain disordersAdult rhesus monkeysDifferent brain disordersDose limitDose-dependent mannerPromising PET radiotracerTest-retest variabilityTest-retest measurementsRadiotracer infusionBrain distributionBolus injectionIntravenous injectionArterial bloodTherapeutic approachesHuman studiesBody weightConstant infusionMonkey brainDistribution volumeInvasive method