Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritis
Katyal P, Hettinghouse A, Meleties M, Hasan S, Chen C, Cui M, Sun G, Menon R, Lin B, Regatte R, Montclare J, Liu C. Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritis. Biomaterials 2022, 281: 121370. PMID: 35032910, PMCID: PMC9055922, DOI: 10.1016/j.biomaterials.2022.121370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnterior Cruciate Ligament InjuriesBiocompatible MaterialsCartilage, ArticularGelsOsteoarthritisPolymersProgranulinsRabbitsConceptsUnique stimuli-responsive propertiesProtein block polymersC gelStimuli-responsive propertiesProtein-based gelsSustained deliveryProtein-based biomaterialsBlock polymersPolymer gelsNetworked gelsProlonged releaseSynthetic materialsGelTherapeutic applicationsInjectable biomaterialsExcellent candidatePhysiological temperatureTherapeutic proteinsModular natureBiomaterialsBiomechanical environmentPolymersProspective therapeuticsRabbit anterior cruciate ligament transection (ACLT) model