2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsCholinergic AgentsHippocampusNeuronal PlasticitySynapsesSynaptic TransmissionConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2019
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu CQ, Barberis A, Higley MJ. Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nature Reviews Neuroscience 2019, 20: 272-281. PMID: 30837689, DOI: 10.1038/s41583-019-0141-5.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBrainGABAergic NeuronsNeural InhibitionNeuronal PlasticitySynapsesConceptsGABAergic synaptic plasticityInhibitory GABAergic synapsesPostsynaptic action potentialsInhibitory synaptic strengthGABAergic synapsesSynaptic excitationLong-term plasticityGlutamatergic signalingNeuronal activitySynaptic plasticityNeuronal circuitsAction potentialsSynaptic strengthIndividual neuronsCellular mechanismsLines of evidenceBody of literaturePlasticityNeuronsFunctional stabilitySynapses
2011
Long-term plasticity at inhibitory synapses
Castillo P, Chiu C, Carroll R. Long-term plasticity at inhibitory synapses. Current Opinion In Neurobiology 2011, 21: 328-338. PMID: 21334194, PMCID: PMC3092861, DOI: 10.1016/j.conb.2011.01.006.Peer-Reviewed Original ResearchConceptsSynaptic plasticityInhibitory synaptic plasticityModification of neural circuitsNeural circuitsNeural circuit refinementNeural circuit functionGABAergic plasticityRegulate excitabilityExcitatory/inhibitory balanceInhibitory plasticityCircuit refinementExcitatory synapsesLong-term plasticitySynaptic efficacyFunctional relevanceCircuit functionDiverse mechanismsLTP/LTDEfficacySynapses
2010
Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Südhof T. RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. Journal Of Neuroscience 2008, 28: 13435-13447. PMID: 19074017, PMCID: PMC2701653, DOI: 10.1523/jneurosci.3235-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExcitatory Postsynaptic PotentialsGTP-Binding ProteinsHippocampusMiceMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsOrgan Culture TechniquesPatch-Clamp TechniquesPresynaptic TerminalsPromoter Regions, GeneticProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSynapsesSynaptic TransmissionSynaptic VesiclesConceptsRIM1 geneActive zone proteinsKnock-out miceSynaptic vesicle primingPresynaptic long-term plasticitySynaptic vesicle proteinsNeurotransmitter releaseLong-term presynaptic plasticityVesicle primingActive zoneMultidomain proteinsSynaptotagmin-1Vesicle proteinsRIM1alphaN-terminusRIM1Plasma membranePresynaptic plasticityDeletionGenesSynaptic functionPresynaptic terminalsProteinIsoformsShort-term synaptic plasticity
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide