2020
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
Fuenzalida M, Chiu C, Chávez A. Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience 2020, 456: 50-59. PMID: 32828940, DOI: 10.1016/j.neuroscience.2020.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsCholinergic AgentsHippocampusNeuronal PlasticitySynapsesSynaptic TransmissionConceptsSpike timing dependent synaptic plasticityTiming-dependent plasticityCellular basis of learningMagnitude of long-term changesMuscarinic receptorsInhibitory synapsesMuscarinic regulationSynaptic transmissionSynaptic plasticityShape learningCentral synapsesBasis of learningCellular basisNetwork activityBrain network activityLong-term changesAcetylcholineHippocampusLearningSynapsesSTDPBrainMuscarinicMemoryReceptors
2013
Wavelength-Selective One- and Two-Photon Uncaging of GABA
Amatrudo JM, Olson JP, Lur G, Chiu CQ, Higley MJ, Ellis-Davies GC. Wavelength-Selective One- and Two-Photon Uncaging of GABA. ACS Chemical Neuroscience 2013, 5: 64-70. PMID: 24304264, PMCID: PMC3894722, DOI: 10.1021/cn400185r.Peer-Reviewed Original Research
2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapses
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions
Kaeser P, Kwon H, Chiu C, Deng L, Castillo P, Südhof T. RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions. Journal Of Neuroscience 2008, 28: 13435-13447. PMID: 19074017, PMCID: PMC2701653, DOI: 10.1523/jneurosci.3235-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExcitatory Postsynaptic PotentialsGTP-Binding ProteinsHippocampusMiceMice, KnockoutNeuronal PlasticityNeurotransmitter AgentsOrgan Culture TechniquesPatch-Clamp TechniquesPresynaptic TerminalsPromoter Regions, GeneticProtein IsoformsReverse Transcriptase Polymerase Chain ReactionSynapsesSynaptic TransmissionSynaptic VesiclesConceptsRIM1 geneActive zone proteinsKnock-out miceSynaptic vesicle primingPresynaptic long-term plasticitySynaptic vesicle proteinsNeurotransmitter releaseLong-term presynaptic plasticityVesicle primingActive zoneMultidomain proteinsSynaptotagmin-1Vesicle proteinsRIM1alphaN-terminusRIM1Plasma membranePresynaptic plasticityDeletionGenesSynaptic functionPresynaptic terminalsProteinIsoformsShort-term synaptic plasticity