2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapses
2010
Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence