2022
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza R, Ancatén-González C, Chiu C, Chávez A. Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Frontiers In Cellular Neuroscience 2022, 16: 864828. PMID: 35518644, PMCID: PMC9062234, DOI: 10.3389/fncel.2022.864828.Peer-Reviewed Original ResearchTransient receptor potential vanilloid 1Synaptic plasticityTRPV1 functionActivity-dependent synaptic changesLigand-gated nonselective cation channelCentral synapsesNonselective cation channelsRegulate synaptic functionVanilloid 1Pain sensationCation channelsHealth and DiseaseSynaptic efficacySynaptic changesBrain regionsPostsynaptic compartmentsNeurotransmitter releasePresynaptic terminalsTherapeutic treatmentSynaptic functionBrain disordersPotential roleSynapsesBrainPain
2010
Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex
Chiu C, Puente N, Grandes P, Castillo P. Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. Journal Of Neuroscience 2010, 30: 7236-7248. PMID: 20505090, PMCID: PMC2905527, DOI: 10.1523/jneurosci.0736-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBenzoxazinesCannabinoid Receptor ModulatorsChelating AgentsDopamineDopamine AgentsEgtazic AcidEndocannabinoidsFemaleGamma-Aminobutyric AcidIn Vitro TechniquesInhibitory Postsynaptic PotentialsIsoquinolinesMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMorpholinesNaphthalenesNeuronal PlasticityPatch-Clamp TechniquesPiperidinesPrefrontal CortexProtein Kinase InhibitorsPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1Receptors, Dopamine D2Silver StainingSulfonamidesSynapsesConceptsPrefrontal cortexI-LTDECB-mediated long-term depressionLong-term depression of inhibitory transmissionPrefrontal cortex of ratsDopamine type 2 receptorPrefrontal cortical functionEndocannabinoid-mediated plasticityEndogenous cannabinoid receptorsGroup I metabotropic glutamate receptorsCannabinoid receptor systemSuppress GABA releaseECB signalingECB-LTDWorking memoryDopaminergic modulationCannabinoid receptorsBrain regionsGABA releaseDopamineEmotional learningCortical functionInhibitory transmissionGABAergic synapsesElectrophysiological evidence