2023
Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Luo X, Lin X, Ide J, Luo X, Zhang Y, Xu J, Wang L, Chen Y, Cheng W, Zheng J, Wang Z, Yu T, Taximaimaiti R, Jing X, Wang X, Cao Y, Tan Y, Li C. Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain. Child And Adolescent Psychiatry And Mental Health 2023, 17: 4. PMID: 36609385, PMCID: PMC9824933, DOI: 10.1186/s13034-022-00536-0.Peer-Reviewed Original ResearchGray matter volumeAttention deficit hyperactivity disorderTotal intracranial volumeSubcortical gray matter volumesMRNA expressionBasal gangliaEuropean cohortABCD cohortMatter volumeCerebral gray matter volumeRisk of ADHDPathogenesis of ADHDGene-wide association studyAmygdala gray matter volumeRegulatory effectsDeficit hyperactivity disorderBrain cohortSubcortical regionsBrain regionsIntracranial volumeCohortSubcortical structuresADHD risk allelesADHD riskHyperactivity disorder
2022
Subcortical structures associated with childhood trauma and perceived stress in schizophrenia
Fan F, Tan S, Liu S, Chen S, Huang J, Wang Z, Yang F, Li CR, Tan Y. Subcortical structures associated with childhood trauma and perceived stress in schizophrenia. Psychological Medicine 2022, 53: 5654-5662. PMID: 36154670, DOI: 10.1017/s0033291722002860.Peer-Reviewed Original ResearchConceptsGray matter volumeAmygdala gray matter volumeSubcortical gray matter volumesClinical symptomsEarly life traumaChildhood traumaSubcortical structuresCortical gray matter volumePerceived stressTotal cortical gray matter volumeAge-matched controlsSmaller amygdala volumesStructural brain imagingClinical featuresClinical manifestationsTrauma ScoreHealthy controlsChildhood trauma scoresLong-term effectsAmygdala volumePatientsMatter volumeEarly childhood traumaSmaller amygdalaVolumetric correlatesAlcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence
Luo X, Yang JJ, Buu A, Trucco EM, Li C. Alcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence. Addiction Biology 2022, 27: e13208. PMID: 36001427, PMCID: PMC9413216, DOI: 10.1111/adb.13208.Peer-Reviewed Original ResearchConceptsGray matter volumeLate adolescenceCaudal middle frontal cortexEarly adolescent onsetGray matter volumetric changesMiddle frontal cortexSevere alcohol useBrain developmentCross-sectional findingsSocial cognitionExecutive controlNCANDA studyVolumetric declinesSupramarginal gyrusPotential sex differencesSuperior temporalImpact of alcoholAdolescent onsetSubstance useCortical regionsAlcohol useMatter volumeFrontal cortexResult of alcoholMixed-effects modelingOvernight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers
Chen Y, Dhingra I, Chaudhary S, Fucito L, Li CR. Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers. Nicotine & Tobacco Research 2022, 24: 1889-1897. PMID: 35796689, PMCID: PMC9653081, DOI: 10.1093/ntr/ntac168.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityGray matter volumeWithdrawal symptom severityOvernight abstinenceFunctional connectivityRight SIISymptom severityCigarette smokersSomatosensory cortexMatter volumeRight secondary somatosensory cortexSmaller gray matter volumeSubcortical gray matter volumesSecond somatosensory cortexSecondary somatosensory cortexCortical functional connectivityMotor impulsivityVoxel-wise morphometryRegional gray matter volumeLeft ventral hippocampusGMV alterationsCigarette smokingSatiety stateAbstinence symptomsHigher-order sensory corticesSex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced qualityStriatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data
Chen Y, Li C. Striatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data. Journal Of Experimental Psychopathology 2022, 13: 20438087221080057. DOI: 10.1177/20438087221080057.Peer-Reviewed Original Research
2021
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking
Chen Y, Chaudhary S, Wang W, Li C. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction Neuroscience 2021, 1: 100003. PMID: 37220533, PMCID: PMC10201991, DOI: 10.1016/j.addicn.2021.100003.Peer-Reviewed Original ResearchGray matter volumeAnterior cingulate cortexYears of smokingHeavy smokersMatter volumeCingulate cortexSalience networkSmaller gray matter volumeSupplementary motor areaNicotine dependence scoresDorsal anterior cingulate cortexVoxel-based morphometryStructural imaging studiesMedial prefrontal cortexInternalizing scoresChronic smokingCigarette smokingFagerstrom TestInsula gray matter volumeMotor areaNicotine addictionSmokersSmokingImaging studiesDependence scoresPerceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults
Li G, Le TM, Wang W, Zhornitsky S, Chen Y, Chaudhary S, Zhu T, Zhang S, Bi J, Tang X, Li CR. Perceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults. NeuroImage Clinical 2021, 32: 102866. PMID: 34749288, PMCID: PMC8569726, DOI: 10.1016/j.nicl.2021.102866.Peer-Reviewed Original ResearchConceptsGray matter volumePerceived stressNeural markersRegional cortical thicknessCortical structuresAlcohol use behaviorsNon-binge drinkersHuman Connectome ProjectChronic alcohol exposure altersCortical thicknessVoxel-based morphometryEmotional distressConnectome ProjectDrinking menPath analysisCortical regionsDrinking womenBinge drinkingMatter volumeYoung adultsUse behaviorsStress regulationPCC thicknessBingeAlcohol exposure altersIdentification of Binge Drinkers via Convolutional Neural Network and Support Vector Machine
Li G, Du S, Niu J, Zhang Z, Gao T, Tang X, Wang W, Li C. Identification of Binge Drinkers via Convolutional Neural Network and Support Vector Machine. 2021, 00: 715-720. DOI: 10.1109/icma52036.2021.9512720.Peer-Reviewed Original ResearchConvolutional neural networkNeural networkGray matter volumeSVM modelSupport vector machineNon-binge drinkersVector machine modelDeep learningVector machinePsychosocial measuresTraining samplesBinge drinkingYoung adult binge drinkingMachine modelAdult binge drinkingHuman Connectome ProjectNetworkPsychosocial markersClassificationConnectome ProjectBinge drinkersCortical thicknessMatter volumeBingeVolumetric differencesAn independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample
2020
Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity
Hung CC, Liu YH, Huang CC, Chou CY, Chen CM, Duann JR, Li CR, Lee TS, Lin CP. Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity. Scientific Reports 2020, 10: 15488. PMID: 32968108, PMCID: PMC7512006, DOI: 10.1038/s41598-020-72320-z.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral gray matter volumeKetamine exposureFunctional connectivityMatter volumeKetamine usersBrain structuresLower gray matter volumeFunctional brain changesTreatment of depressionAdolescent-onset groupCerebral functional organizationHigher functional connectivitySuperior frontal gyrusInferior parietal lobuleMedial orbitofrontal cortexSeed-based correlation analysisKetamine groupBrain changesKetamine abuseLarge cohortRight insulaLeft precuneusKetamine misuseRight precuneusCommon and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areasGray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data
Ide JS, Li HT, Chen Y, Le TM, Li CSP, Zhornitsky S, Li CR. Gray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data. NeuroImage 2020, 220: 117085. PMID: 32592852, PMCID: PMC7572877, DOI: 10.1016/j.neuroimage.2020.117085.Peer-Reviewed Original ResearchConceptsBehavioral activation systemBehavioral inhibition systemGray matter volumeHigher BAS scoresVentral striatumBAS scoresInhibition systemBIS scoresInferior frontal cortexFundamental behavioral traitsTwins/siblingsRight anterior insulaHigher BIS scoresNeural correlatesDevelopmental neuroscienceAnterior insulaVolumetric correlatesVoxel-based morphometry studyInternalizing psychopathologyCerebral basisVoxel-based morphometryBehavioral activationVentral caudateAvoidance traitsMatter volumeKTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease
Mao Q, Wang X, Chen B, Fan L, Wang S, Zhang Y, Lin X, Cao Y, Wu YC, Ji J, Xu J, Zheng J, Zhang H, Zheng C, Chen W, Cheng W, Luo X, Wang K, Zuo L, Kang L, Li CR, Luo X. KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease. Frontiers In Neuroscience 2020, 14: 651. PMID: 32655362, PMCID: PMC7324786, DOI: 10.3389/fnins.2020.00651.Peer-Reviewed Original ResearchPutamen gray matter volumesSubstantia nigra pars compactaGray matter volumeParkinson's diseaseMRNA expressionSingle nucleotide polymorphismsPD riskIndependent cohortMatter volumeDevelopment of PDPars compactaDopaminergic neuronsPutamenPutamen volumeSignificant associationPD associationsRisk allelesDiseaseSelective lossCohortGene variants
2019
The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus
Le TM, Liao DL, Ide J, Zhang S, Zhornitsky S, Wang W, Li CR. The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus. International Journal Of Obesity 2019, 44: 1097-1107. PMID: 31796869, PMCID: PMC8643195, DOI: 10.1038/s41366-019-0496-8.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityWhole-brain multiple regressionGray matter volumeInsula connectivityBody mass indexFunctional connectivitySeed-based resting-state functional connectivityMatter volumeSuperior parietal lobuleVoxel-based morphometry analysisMultiple regressionConclusionsThe current findingsBody weightCognitive controlMultiple brain circuitsBrain mechanismsIndividual differencesInhibitory controlParietal lobuleHypothalamic connectivityMass indexMediation analysisBrain circuitsHigher body mass indexCurrent findingsProblem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood imagesPutamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.
Luo X, Mao Q, Shi J, Wang X, Li CR. Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders. World Journal Of Psychiatry And Mental Health Research 2019, 3 PMID: 31328186, PMCID: PMC6641567.Peer-Reviewed Original ResearchGray matter volumePutamen volumeNeurodegenerative disordersMatter volumePutamen gray matter volumesSpectrum disorderParkinson's spectrum disordersAttention deficit hyperactivity disorderSchizophrenia spectrum disordersDeficit hyperactivity disorderMultiple sclerosisLewy bodiesObsessive-compulsive spectrum disordersMajor depressionTreatment outcomesMotor impairmentDopaminergic processesNeurodegenerative conditionsAmphetamine dependenceBipolar disorderAlzheimer's diseaseCognitive deficitsHuntington's diseaseDiseaseHyperactivity disorder
2018
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects
Mackey S, Allgaier N, Chaarani B, Spechler P, Orr C, Bunn J, Allen NB, Alia-Klein N, Batalla A, Blaine S, Brooks S, Caparelli E, Chye YY, Cousijn J, Dagher A, Desrivieres S, Feldstein-Ewing S, Foxe JJ, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hester R, Hutchison K, Korucuoglu O, Li CR, London E, Lorenzetti V, Luijten M, Martin-Santos R, May A, Momenan R, Morales A, Paulus MP, Pearlson G, Rousseau ME, Salmeron BJ, Schluter R, Schmaal L, Schumann G, Sjoerds Z, Stein DJ, Stein EA, Sinha R, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Whittle S, Wiers R, Wright M, Yücel M, Zhang S, Yurgelun-Todd D, Hibar D, Jahanshad N, Evans A, Thompson P, Glahn D, Conrod P, Garavan H. Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. American Journal Of Psychiatry 2018, 176: 119-128. PMID: 30336705, PMCID: PMC6427822, DOI: 10.1176/appi.ajp.2018.17040415.Peer-Reviewed Original ResearchConceptsRegional brain volumesControl subjectsSubstance dependenceBrain volumeBrain regionsLower brain volumeAlcohol use disorderGray matter volumeTotal intracranial volumeMedial orbitofrontal cortexCommon neural substrateCortical thicknessUse disordersUseful biomarkerMatter volumeSubcortical volumesImaging biomarkersAlcohol dependenceIntracranial volumeOrbitofrontal cortexRegional volumesBrain structuresRelevant imaging biomarkersLow volumeNeural substrates