2023
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2019
Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers
Wang W, Zhornitsky S, Le TM, Zhang S, Li CR. Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 619-628. PMID: 32061544, PMCID: PMC7286768, DOI: 10.1016/j.bpsc.2019.12.013.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestProblem alcohol useHeart rate variabilityCue exposureAlcohol useAUDIT scoresAutonomic responsesRate variabilityNeutral cue exposureCue exposure paradigmDisorders Identification TestAlcohol cue exposurePrefrontal cortical responsesVentromedial prefrontal cortex activityAlcohol drinkersPrefrontal cortex activityHigher RMSSDCortical responsesParasympathetic responseAlcohol cravingAlcohol misuseVentromedial prefrontal cortexExposure paradigmCortex activityMediation analysisProblem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood images
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectancies
2016
Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers
Hu S, Zhang S, Chao HH, Krystal JH, Li CS. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcohol Clinical And Experimental Research 2016, 40: 319-328. PMID: 26833431, PMCID: PMC4742397, DOI: 10.1111/acer.12964.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestYears of drinkingStop-signal reaction timeAlcohol useAge-related changesAlcohol misuseInhibitory controlAUDIT scoresDrinking problemsNondependent drinkersProlonged stop signal reaction timeChronic alcohol useAnterior cingulate cortexPresupplementary motor areaDisorders Identification TestRight inferior frontal gyrusResponse inhibitionSuperior temporal gyrusYoung adult social drinkersFunctional magnetic resonanceAdult social drinkersSignal reaction timeCerebral responsesInferior frontal gyrusHigher AUDIT