2006
Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *
Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila *. Journal Of Biological Chemistry 2006, 281: 28097-28104. PMID: 16861233, DOI: 10.1074/jbc.m601642200.Peer-Reviewed Original ResearchConceptsMelanization cascadeMelanization reactionResistance of DrosophilaDownstream proteasesDrosophilaKey enzymeMicrobial pathogensGenetic characterizationMelanin synthesisSerine proteasesMelanizationProteasePathogenic bacteriaMicrobial infectionsMP1PhenoloxidaseFungal infectionsCascadeImportant roleImmune systemSpn27AArthropodsFungiEnzymeBacteria
2003
Spatial Regulation of Developmental Signaling by a Serpin
Hashimoto C, Kim DR, Weiss LA, Miller JW, Morisato D. Spatial Regulation of Developmental Signaling by a Serpin. Developmental Cell 2003, 5: 945-950. PMID: 14667416, DOI: 10.1016/s1534-5807(03)00338-1.Peer-Reviewed Original ResearchConceptsExtracellular serine protease cascadeDiverse biological processesSerine protease cascadeDevelopmental signalingDrosophila embryosDorsoventral polarityBlood-clotting cascadeSpatial regulationSerine protease inhibitorProtease cascadeBiological processesGeneral mechanismEssential roleProtease activitySpatial controlEmbryosCascadeProtease inhibitorsVentral sideMammalianSerpinsSignalingRegulationPathwayRole