2024
Modeling lung adenocarcinoma metastases using patient-derived organoids
Liu Y, Lankadasari M, Rosiene J, Johnson K, Zhou J, Bapat S, Chow-Tsang L, Tian H, Mastrogiacomo B, He D, Connolly J, Lengel H, Caso R, Dunne E, Fick C, Rocco G, Sihag S, Isbell J, Bott M, Li B, Lito P, Brennan C, Bilsky M, Rekhtman N, Adusumilli P, Mayo M, Imielinski M, Jones D. Modeling lung adenocarcinoma metastases using patient-derived organoids. Cell Reports Medicine 2024, 5: 101777. PMID: 39413736, PMCID: PMC11513837, DOI: 10.1016/j.xcrm.2024.101777.Peer-Reviewed Original ResearchConceptsMetastasis modelLung adenocarcinomaAutologous peripheral blood mononuclear cellsEarly-stage lung cancerMechanisms of drug resistancePeripheral blood mononuclear cellsBlood mononuclear cellsEfficacy of treatmentLung cancer metastasisLung adenocarcinoma metastasisDistant metastasisStudy clonalityAdenocarcinoma metastasisLung cancerMononuclear cellsDrug resistanceMetastasisSuppress metastasisIndividual patientsTumor evolutionCancer metastasisHuman metastasesPatientsBiological featuresRNA sequencing
2023
Mediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy
Dunne E, Fick C, Jones D. Mediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy. Journal Of Clinical Oncology 2023, 41: 3785-3790. PMID: 37267507, PMCID: PMC10419653, DOI: 10.1200/jco.23.00867.Peer-Reviewed Original ResearchConceptsMediastinal lymph nodesCell lung cancerConfirmatory mediastinoscopyFine-needle aspirationPositron emission tomographyLymph nodesNodal metastasisEBUS-FNALung cancerEndobronchial ultrasound-guided fine-needle aspirationOncology Grand Rounds seriesNegative findingsUltrasound-guided fine-needle aspirationThoracic Surgeons guidelinesRandomized noninferiority trialStandard of careTumor genomic analysisOwn clinical practiceResectable NSCLCN1 diseaseNodal diseaseMediastinal stagingAccurate stagingForceps biopsySurgeons guidelinesGenomic mapping of metastatic organotropism in lung adenocarcinoma
Lengel H, Mastrogiacomo B, Connolly J, Tan K, Liu Y, Fick C, Dunne E, He D, Lankadasari M, Satravada B, Sun Y, Kundra R, Fong C, Smith S, Riely G, Rudin C, Gomez D, Solit D, Berger M, Li B, Mayo M, Matei I, Lyden D, Adusumilli P, Schultz N, Sanchez-Vega F, Jones D. Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer Cell 2023, 41: 970-985.e3. PMID: 37084736, PMCID: PMC10391526, DOI: 10.1016/j.ccell.2023.03.018.Peer-Reviewed Original ResearchConceptsActionable alterationsPrimary tumorMetastasis-free survivalHigh mutational burdenAPOBEC mutational signatureSolid histological subtypeMetastatic burdenClinicopathological featuresHistological subtypesLung adenocarcinomaMutational burdenLiver lesionsInactivation of TP53Tumor genomicsMetastasisMetastatic organotropismUnknown significanceGenomic alterationsOrganotropismMutational signaturesTumorsNumber alterationsAlterationsBurdenChromosomal instability
2021
Patellofemoral kinematics in patellofemoral pain syndrome: The influence of demographic factors
Fick CN, Jiménez-Silva R, Sheehan FT, Grant C. Patellofemoral kinematics in patellofemoral pain syndrome: The influence of demographic factors. Journal Of Biomechanics 2021, 130: 110819. PMID: 34749164, PMCID: PMC10311921, DOI: 10.1016/j.jbiomech.2021.110819.Peer-Reviewed Original ResearchConceptsBody mass indexPatellofemoral painPatellofemoral kinematicsThree-dimensional patellofemoral kinematicsExact causePatellar shiftPatellofemoral pain syndromePF kinematicsPain syndromeMass indexRetrospective studyMature patientsPatient cohortPF painHealthy controlsPatellar tiltPainSuperior displacementModifiable measuresMultifactorial natureClinical interventionsWeight lossDemographic matchingPatellar flexionGroup differences
2020
A Word of Caution for Future Studies in Patellofemoral Pain: A Systematic Review With Meta-analysis
Grant C, Fick CN, Welsh J, McConnell J, Sheehan FT. A Word of Caution for Future Studies in Patellofemoral Pain: A Systematic Review With Meta-analysis. The American Journal Of Sports Medicine 2020, 49: 538-551. PMID: 32816535, PMCID: PMC9906796, DOI: 10.1177/0363546520926448.Peer-Reviewed Original ResearchConceptsPatellofemoral painPatellofemoral kinematicsSystematic reviewCase-control studyUnderlying mechanismQuality assessment checklistMethodological variabilityWeb of SciencePatient characteristicsCofounding variablesGreater effect sizePatellar maltrackingPrevious traumaPainMaltrackingDiagnostic valueTherapy efficacyLateral maltrackingLiterature searchFull extensionLarge methodological variabilityAssessment checklistClinical communityWord of cautionPrimary aimCurrent Management of Extraperitoneal Bladder Injuries: Results from the Multi-Institutional Genito-Urinary Trauma Study (MiGUTS).
Anderson RE, Keihani S, Moses RA, Nocera AP, Selph JP, Castillejo Becerra CM, Baradaran N, Glavin K, Broghammer JA, Arya CS, Sensenig RL, Rezaee ME, Morris BJ, Majercik S, Hewitt T, Burks FN, Schwartz I, Elliott SP, Luo-Owen X, Mukherjee K, Thomsen PB, Erickson BA, Miller BD, Santucci RA, Allen L, Norwood S, Fick CN, Smith BP, Piotrowski J, Dodgion CM, DeSoucy ES, Zakaluzny S, Kim DY, Breyer BN, Okafor BU, Askari R, Lucas JW, Simhan J, Khabiri SS, Nirula R, Myers JB. Current Management of Extraperitoneal Bladder Injuries: Results from the Multi-Institutional Genito-Urinary Trauma Study (MiGUTS). Journal Of Urology 2020, 204: 538-544. PMID: 32259467, PMCID: PMC8717861, DOI: 10.1097/ju.0000000000001075.Peer-Reviewed Original ResearchConceptsExtraperitoneal bladder injuriesBladder neck injuryBladder injuryOperative repairCatheter drainageInitial managementNeck injuriesLevel 1 trauma centerLarge multi-institutional cohortIntraperitoneal bladder injuryInitial management strategyMulti-institutional cohortSignificant predictorsSeverity of injuryCurrent management trendsConcomitant injuriesHospital arrivalUrethral injuryBladder neckSurgical repairTrauma centerSignificant complicationsPelvic fracturesBladder traumaRepair group
2019
The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions.
Keihani S, Rogers DM, Putbrese BE, Anderson RE, Stoddard GJ, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller BD, Santucci RA, Carrick MM, Allen L, Norwood S, Hewitt T, Burks FN, Heilbrun ME, Gross JA, Myers JB. The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions. Journal Of Trauma And Acute Care Surgery 2019, 88: 357-365. PMID: 31876692, DOI: 10.1097/ta.0000000000002572.Peer-Reviewed Original ResearchConceptsHigh-grade renal traumaAAST grading systemComputed tomography scanGrading systemAAST gradingTomography scanMixed-effects multivariable logistic regressionInitial computed tomography (CT) scanLevel 1 trauma centerGrade IV injuriesGrade V injuriesNon-operative managementMultivariable logistic regressionSurgery of TraumaImportant radiologic findingsAmerican AssociationRenal traumaRadiologic findingsTrauma centerGrade IIIInjury patternsGrade reclassificationEpidemiological studiesLevel IIIControl interventionsPatellofemoral Pain in Adolescents: Understanding Patellofemoral Morphology and Its Relationship to Maltracking
Fick CN, Grant C, Sheehan FT. Patellofemoral Pain in Adolescents: Understanding Patellofemoral Morphology and Its Relationship to Maltracking. The American Journal Of Sports Medicine 2019, 48: 341-350. PMID: 31834811, PMCID: PMC8167821, DOI: 10.1177/0363546519889347.Peer-Reviewed Original ResearchConceptsPatellar height ratioPatellofemoral painPatellofemoral morphologyPatellar widthPatellofemoral pain groupHealthy adolescent controlsCross-sectional studyLevel of evidenceLateral patellar tiltLateral trochlear inclinationPain cohortPain etiologyPain groupAdolescent patientsFemoral shaft lengthPatellar tiltLarge sulciMultifactorial etiologyPainMedial shiftCartilage lengthMagnetic resonance imagesEtiologyPatellar shiftTrochlear inclinationMelorheostosis
Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T. Melorheostosis. The American Journal Of Surgical Pathology 2019, 43: 1554-1559. PMID: 31386640, PMCID: PMC7832124, DOI: 10.1097/pas.0000000000001310.Peer-Reviewed Original ResearchConceptsClinical presentationBone biopsyCortical bone depositionProminent cement linesPatient's clinical presentationCommon histologic findingsRadiologic patternsPathologic findingsRadiographic findingsHistologic patternHistologic findingsDifferential diagnosisBone diseaseDripping candle waxDense cortical boneMelorheostosisPatientsMultiple patientsClinical pathologistsBone depositionCortical boneBiopsyDiagnosisDistinct patternsBoneThe associations between initial radiographic findings and interventions for renal hemorrhage after high-grade renal trauma: Results from the Multi-Institutional Genitourinary Trauma Study.
Keihani S, Putbrese BE, Rogers DM, Zhang C, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB. The associations between initial radiographic findings and interventions for renal hemorrhage after high-grade renal trauma: Results from the Multi-Institutional Genitourinary Trauma Study. Journal Of Trauma And Acute Care Surgery 2019, 86: 974-982. PMID: 31124895, DOI: 10.1097/ta.0000000000002254.Peer-Reviewed Original ResearchConceptsHigh-grade renal traumaVascular contrast extravasationInitial radiographic findingsRadiographic findingsCertain radiographic findingsRenal traumaLaceration sizeMixed-effects Poisson regressionRisk of interventionRenal angioembolizationContrast extravasationRenal injuryRenal hemorrhageUnivariable analysisMulticenter studySurgical packingPartial nephrectomyDeep lacerationsTomography scanMultivariable modelLevel IVEpidemiological studiesInjury mechanismLevel IOptimal cutoffOptimal timing of delayed excretory phase computed tomography scan for diagnosis of urinary extravasation after high-grade renal trauma
Keihani S, Putbrese BE, Rogers DM, Patel DP, Stoddard GJ, Hotaling JM, Nirula R, Luo-Owen X, Mukherjee K, Morris BJ, Majercik S, Piotrowski J, Dodgion CM, Schwartz I, Elliott SP, DeSoucy ES, Zakaluzny S, Sherwood BG, Erickson BA, Baradaran N, Breyer BN, Fick CN, Smith BP, Okafor BU, Askari R, Miller B, Santucci RA, Carrick MM, Kocik JF, Hewitt T, Burks FN, Heilbrun ME, Myers JB. Optimal timing of delayed excretory phase computed tomography scan for diagnosis of urinary extravasation after high-grade renal trauma. Journal Of Trauma And Acute Care Surgery 2019, 86: 274-281. PMID: 30605143, DOI: 10.1097/ta.0000000000002098.Peer-Reviewed Original ResearchConceptsHigh-grade renal traumaInitial CT scanUrinary extravasationRenal collecting system injuryRenal traumaExcretory phaseCT scanSystem injuryTomography scanOptimal timingPhase CT scansInitial CTMedian timeLevel ICutoff pointExtravasationPoisson regressionLevel IIIAccurate diagnosisDiagnosisPhase timingAccurate gradingTraumaScansPatients
2011
Medical marijuana: Medical necessity versus political agenda
Clark PA, Capuzzi K, Fick C. Medical marijuana: Medical necessity versus political agenda. Medical Science Monitor 2011, 17: ra249-ra261. PMID: 22129912, PMCID: PMC3628147, DOI: 10.12659/msm.882116.Peer-Reviewed Original ResearchConceptsDrug Enforcement AgencyChronic non-cancer painNon-cancer painMedical marijuanaSchedule II drugsBenefits of marijuanaMultiple sclerosisMuscle spasmSchedule I drugBeneficial treatmentWasting syndromePatientsMedical necessityDistrict of ColumbiaDrugsMarijuanaPhysiciansRelevant scientific dataRecent studiesMedical useVomitingNauseaPainSpasmChemotherapy