Featured Publications
High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior
Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, Ruíz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, García-de la Cruz DD, López-Armenta M, Real F, García-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, Rodríguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.Peer-Reviewed Original ResearchMeSH KeywordsDNA MethylationEpigenesis, GeneticHumansMultifactorial InheritanceSuicidal IdeationSuicide, AttemptedConceptsDNA methylation differencesMethylation differencesDiscovery samplePolygenic risk scoresDNA methylation changesSuicidal behaviorGenetic burdenPolygenic burdenPsychiatric Genomics ConsortiumEpigenetic variationATP bindingDNA methylationEnvironmental factorsMethylation changesEpigenetic changesGenomics ConsortiumPolygenic componentGenesGenetic variantsPRS analysesRisk scoreMexican individualsBurdenIntegration of approachesNeurodevelopment
2023
Sex differences in the polygenic architecture of hearing problems in adults
De Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHearingHumansMaleMultifactorial InheritanceSex CharacteristicsConceptsPolygenic architectureRisk lociGenome-wide investigationLarge-scale genetic studiesTranscriptomic regulationGWAS findingsTranscriptomic associationsGene interactionsPotential roleRegulation analysisGenetic studiesInference analysisMillion Veteran ProgramHealth Professionals FollowMolecular pathwaysPolygenic riskPreventive screening programsMultivariate interaction analysisNovel insightsCentral nervous systemEnvironmental risk factorsSex-stratified analysesSex-specific analysesSex differencesMental health outcomes
2022
Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
Koller D, Wendt F, Pathak G, De Lillo A, De Angelis F, Cabrera-Mendoza B, Tucci S, Polimanti R. Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations. BMC Biology 2022, 20: 249. PMID: 36344982, PMCID: PMC9641937, DOI: 10.1186/s12915-022-01449-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsian PeopleGenome, HumanGenome-Wide Association StudyHumansMultifactorial InheritanceNeanderthalsConceptsArchaic introgressionComplex traitsDenisovan introgressionNeanderthal allelesNeanderthal introgressionSignatures of admixtureAncestry groupsModern populationsPhenome-wide association studyModern human populationsMajor histocompatibility complex regionIntrogressionEvolutionary pressureGenetic poolDisease heritabilityGenomic signaturesEAS populationsExtinct NeanderthalsAssociation studiesMetabolic traitsDenisovansUK BiobankRed hair colorEuropean descentHuman traits