2001
Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells
Li W, Duzgun A, Sumpio B, Basson M. Integrin and FAK-mediated MAPK activation is required for cyclic strain mitogenic effects in Caco-2 cells. AJP Gastrointestinal And Liver Physiology 2001, 280: g75-g87. PMID: 11123200, DOI: 10.1152/ajpgi.2001.280.1.g75.Peer-Reviewed Original ResearchMeSH KeywordsCaco-2 CellsCell DivisionCell MovementCytoskeletal ProteinsEnzyme InhibitorsExtracellular MatrixFlavonoidsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression Regulation, EnzymologicHumansImidazolesIntegrinsIntestinesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesNaphthalenesP38 Mitogen-Activated Protein KinasesPaxillinPhosphoproteinsPhosphorylationProtein-Tyrosine KinasesPyridinesStress, MechanicalTransfectionConceptsFocal adhesion kinaseMAPK extracellular signal-regulated kinaseCaco-2 cellsMitogen-activated protein kinase activationVitro kinase assaysProtein kinase activationSignal-regulated kinaseMitogenic effectProtein kinase C inhibitionBeta1 integrin subunitsCaco-2 proliferationKinase assaysAdhesion kinaseFAK activationERK signalsJNK1 activationKinase activationTerminal kinaseMAPK activationUpstream signalsC-JunFAK inhibitionP38 inhibitionIntegrin subunitsKinase
1998
Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals
Han O, Di Li G, Sumpio B, Basson M. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. American Journal Of Physiology 1998, 275: g534-g541. PMID: 9724266, DOI: 10.1152/ajpgi.1998.275.3.g534.Peer-Reviewed Original Research
1997
Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes
Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio B. Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes. Journal Of Cellular Biochemistry 1997, 67: 327-337. PMID: 9361188, DOI: 10.1002/(sici)1097-4644(19971201)67:3<327::aid-jcb5>3.0.co;2-y.Peer-Reviewed Original Research
1996
Amplitude‐dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco‐2 monolayers
Basson M, Di Li G, Hong F, Han O, Sumpio B. Amplitude‐dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco‐2 monolayers. Journal Of Cellular Physiology 1996, 168: 476-488. PMID: 8707883, DOI: 10.1002/(sici)1097-4652(199608)168:2<476::aid-jcp26>3.0.co;2-#.Peer-Reviewed Original Research
1992
Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro.
Rosales OR, Sumpio BE. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery 1992, 112: 459-66. PMID: 1379381.Peer-Reviewed Original ResearchConceptsProtein kinase CActivation of PKCImmunocytochemical stainingPKC activityCyclic stretchEndothelial cell activationVascular endothelial cellsCycles/minSustained elevationCell activationFlexible-bottomed culture platesKinase CBovine aortic ECsECS resultsEndothelial cellsBlood vesselsAortic ECsEvidence of translocationSpecific PKC inhibitorEC proliferationCalphostin CEC growthHemodynamic forces