2010
Thrombospondin 1, Fibronectin, and Vitronectin are Differentially Dependent Upon RAS, ERK1/2, and p38 for Induction of Vascular Smooth Muscle Cell Chemotaxis
Willis AI, Sadowitz B, Fuse S, Maier KG, Lee TS, Wang XJ, Tuszynski GP, Sumpio BE, Gahtan V. Thrombospondin 1, Fibronectin, and Vitronectin are Differentially Dependent Upon RAS, ERK1/2, and p38 for Induction of Vascular Smooth Muscle Cell Chemotaxis. Vascular And Endovascular Surgery 2010, 45: 55-62. PMID: 21193465, DOI: 10.1177/1538574410387677.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsCattleCells, CulturedChemotaxisFibronectinsHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularMyocytes, Smooth MuscleP38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsRas ProteinsThrombospondin 1TransfectionVitronectinConceptsVascular smooth muscle cellsThrombospondin-1Smooth muscle cell chemotaxisFarnesyl protein transferase inhibitorSignal transduction pathwaysProtein transferase inhibitorsVascular smooth muscle cell chemotaxisBovine vascular smooth muscle cellsTSP-1Ras N17Transduction pathwaysSecond messenger systemsP38Smooth muscle cellsERK1/2VSMC migrationTransferase inhibitorsPD098059Cell chemotaxisSB202190Muscle cellsMessenger systemsVitronectinRAChemotaxis
2003
Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells
Zhang J, Li W, Sumpio BE, Basson MD. Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells. Biochemical And Biophysical Research Communications 2003, 306: 746-749. PMID: 12810082, DOI: 10.1016/s0006-291x(03)01044-1.Peer-Reviewed Original ResearchConceptsIntestinal epithelial responsesIntestinal epithelial proliferationCaco-2 intestinal epithelial cellsIntestinal epithelial cellsHuman Caco-2 intestinal epithelial cellsCaco-2 cellsPlasma fibronectinInfectious conditionsEpithelial responseFibronectin levelsEpithelial proliferationIntestinal epitheliumEpithelial cellsRepetitive forcesBasement membraneCollagen ICollagen IVIntracellular signalingP38JNK activationActivationCellsStrain activationTissueFibronectinRegulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins
Zhang J, Li W, Sanders MA, Sumpio BE, Asit P, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. The FASEB Journal 2003, 17: 1-22. PMID: 12626437, DOI: 10.1096/fj.02-0663fje.Peer-Reviewed Original ResearchMeSH KeywordsCaco-2 CellsCell AdhesionCell DivisionCell LineCollagen Type ICollagen Type IVEnzyme ActivationEpithelial CellsExtracellular Matrix ProteinsFibronectinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansIntegrin alpha5Integrin alphaVIntestinal MucosaLamininMitogen-Activated Protein KinasesPhosphorylationProtein-Tyrosine KinasesStress, MechanicalConceptsExtracellular signal-regulated protein kinaseMatrix proteinsIntestinal epithelial responsesHuman intestinal epithelial proliferationSignal-regulated protein kinaseJun N-terminal kinaseFocal adhesion kinaseIntestinal epithelial biologyMatrix-dependent mannerN-terminal kinaseExtracellular matrix proteinsEpithelial responseCaco-2 proliferationCaco-2BBe cellsIntestinal epithelial proliferationAdhesion kinaseEpidermal growth factorProtein kinaseERK activationEpithelial biologyEpithelial cell proliferationIntegrin subunitsKinaseAnti-integrin antibodiesMEK blockade
2000
Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis
Willis A, Fuse S, Wang X, Chen E, Tuszynski G, Sumpio B, Gahtan V. Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2000, 31: 1160-1167. PMID: 10842153, DOI: 10.1067/mva.2000.106489.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell CountCell DivisionCells, CulturedChemotaxisChromonesEnzyme InhibitorsExtracellular Matrix ProteinsFibronectinsHyperplasiaIndolesMaleimidesMorpholinesMuscle, Smooth, VascularPhosphoinositide-3 Kinase InhibitorsProtein Kinase CSignal TransductionStatistics as TopicThrombospondin 1Tunica IntimaVitronectinConceptsProtein kinase CVSMC migrationLY-294002Thrombospondin-1ECM proteinsKinase CSmooth muscle cell chemotaxisSerum-free mediumCellular signaling pathwaysInhibition of phosphatidylinositolVascular smooth muscle cell chemotaxisVascular smooth muscle cell migrationPI3K inhibitorsSmooth muscle cell migrationSignaling pathwaysMuscle cell migrationBisindolylmaleimide ICell migrationPKC inhibitorGF 109203XExtracellular matrix depositionTop wellsK inhibitorsAortic VSMCsCell chemotaxis