2019
Use of Closed-Incision Negative-Pressure Therapy: Cardiothoracic and Vascular Surgery.
Wu RT, Sumpio BJ, Miller S, Sumpio BE. Use of Closed-Incision Negative-Pressure Therapy: Cardiothoracic and Vascular Surgery. Plastic & Reconstructive Surgery 2019, 143: 31s-35s. PMID: 30586101, DOI: 10.1097/prs.0000000000005310.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overFemaleHumansNegative-Pressure Wound TherapyPostoperative CareSurgical WoundSurgical Wound InfectionThoracic Surgical ProceduresVascular Surgical ProceduresConceptsNegative pressure therapyVascular surgeryClosed incision negative pressure therapyIncision negative pressure therapySurgical site infectionMedian sternotomy infectionsGroin woundsSerious sequelaeSite infectionSternotomy infectionsGauze dressingsTraditional gauze dressingsSurgeryTherapyCardiothoracicInfectionRecent enthusiasmComplicationsSequelae
2010
Retrospective evaluation of clinical outcomes in subjects with split‐thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries
Blume PA, Key JJ, Thakor P, Thakor S, Sumpio B. Retrospective evaluation of clinical outcomes in subjects with split‐thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries. International Wound Journal 2010, 7: 480-487. PMID: 20825510, PMCID: PMC7951281, DOI: 10.1111/j.1742-481x.2010.00728.x.Peer-Reviewed Original ResearchConceptsAnkle reconstructive surgeryConventional therapyGraft survivalNPWT/ROCFClinical outcomesReconstructive surgerySplit-thickness skin graft survivalSplit-thickness skin graftNegative pressure wound therapyDuration of graftImproved graft survivalOverall graft takeVacuum-Assisted TherapySkin graft survivalPressure wound therapyGraft failureRetrospective reviewRetrospective studyOutpatient treatmentGraft takeSkin graftsCT groupWound therapyRetrospective evaluationLevel I
2009
The mechanisms of action of vacuum assisted closure: More to learn
Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: More to learn. Surgery 2009, 146: 40-51. PMID: 19541009, DOI: 10.1016/j.surg.2009.02.002.Peer-Reviewed Original ResearchBacterial InfectionsEdemaGeneral SurgeryHumansNegative-Pressure Wound TherapyNeovascularization, PhysiologicRegional Blood FlowWound Healing
2008
Role of Negative Pressure Wound Therapy in Treating Peripheral Vascular Graft Infections
Sumpio BE, Allie DE, Horvath KA, Marston WA, Meites HL, Mills JL, Orgill DP, Salazar JD, Song DH, Toursarkissian B. Role of Negative Pressure Wound Therapy in Treating Peripheral Vascular Graft Infections. Vascular 2008, 16: 194-200. PMID: 18845099, DOI: 10.2310/6670.2008.00041.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnti-Infective AgentsDiabetic FootFemaleGroinHumansMaleNegative-Pressure Wound TherapyOcclusive DressingsPeripheral Vascular DiseasesPractice Guidelines as TopicProsthesis-Related InfectionsSurgical FlapsSurgical Wound InfectionVascular Surgical ProceduresWound HealingConceptsNegative pressure wound therapyPressure wound therapyGroin infectionWound therapyRole of NPWTLarger subcutaneous vesselsVascular graft infectionVascular surgical proceduresDiabetic foot ulcersOpen abdominal woundsGraft infectionWound complicationsFoot ulcersSurgical closureTreatment modalitiesBody of evidenceVascular surgeryAbdominal woundsLarge blood vesselsConsensus panelSurgical proceduresSubcutaneous vesselsComplex woundsProblematic woundsClinical practice
2007
Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival
Nishimura K, Blume P, Ohgi S, Sumpio BE. Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival. Wound Repair And Regeneration 2007, 15: 646-656. PMID: 17971010, DOI: 10.1111/j.1524-475x.2007.00295.x.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseP38 mitogen-activated protein kinaseMAPK/ERK kinaseExtracellular signal-regulated kinaseDominant-negative AktHuman dermal fibroblastsSignal-regulated kinaseCell numberERK kinaseProtein kinaseTransduction pathwaysDermal fibroblastsRelevant transduction pathwaysRelevant signal pathwaysDermal fibroblast proliferationHuman dermal fibroblast proliferationCultured human dermal fibroblastsSurvival of fibroblastsSignal pathwayKinaseNecrotic fibroblastsDNA synthesisCell proliferationAktTransferase-mediated dUTP nick-end labeling staining