2011
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion
Chin A, Svejda B, Gustafsson B, Granlund A, Sandvik A, Timberlake A, Sumpio B, Pfragner R, Modlin I, Kidd M. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. AJP Gastrointestinal And Liver Physiology 2011, 302: g397-g405. PMID: 22038827, PMCID: PMC3287403, DOI: 10.1152/ajpgi.00087.2011.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAdenosine-5'-(N-ethylcarboxamide)AdultAgedCell Line, TumorCells, CulturedColonCrohn DiseaseCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesEnterochromaffin CellsFemaleGene ExpressionHumansMaleMAP Kinase Kinase 1MAP Kinase Signaling SystemMechanotransduction, CellularMiddle AgedPhosphorylationProto-Oncogene Proteins c-aktPurinesReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A2BReceptor, Adenosine A3SerotoninSignal TransductionStress, MechanicalTryptophan HydroxylaseVesicular Monoamine Transport ProteinsConceptsInflammatory bowel diseaseEC cellsCell functionEC cell functionMechanical stimulationDevelopment of agentsSecrete serotoninBowel diseaseIntracellular cAMP levelsGut motilityEnterochromaffin cellsAdenosine responsivenessReceptor agonistReceptor expressionHuman EC cellsSerotonin secretionAdenosine receptorsMRS1754CAMP productionSecretionCAMP levelsNECANeoplasiaMechanosensory cellsDisease
1998
Understanding molecular biology.
Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.Peer-Reviewed Original Research
1997
Endothelial Cell Effect on Smooth Muscle Cell Collagen Synthesis
Powell R, Hydowski J, Frank O, Bhargava J, Sumpio B. Endothelial Cell Effect on Smooth Muscle Cell Collagen Synthesis. Journal Of Surgical Research 1997, 69: 113-118. PMID: 9202656, DOI: 10.1006/jsre.1997.5045.Peer-Reviewed Original ResearchConceptsGene expressionSMC gene expressionExtracellular matrixEndothelial cellsOpposite endothelial cellsEC-SMC interactionsCell lysate fractionTrichloroacetic acid-precipitable countsCollagen synthesis regulationSynthesis regulationSMC DNANorthern analysisBovine aortic SMCEndothelial cell effectsLysate fractionAcid-precipitable countsType IAortic SMCsCollagen synthesisMatrigelSubstrate compositionCulture substrateType I collagenFibronectinExpression