1999
Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
Li S, Chen B, Azuma N, Hu Y, Wu S, Sumpio B, Shyy J, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. Journal Of Clinical Investigation 1999, 103: 1141-1150. PMID: 10207166, PMCID: PMC408275, DOI: 10.1172/jci5367.Peer-Reviewed Original ResearchAnimalsBiological TransportCalcium-Calmodulin-Dependent Protein KinasesCattleCdc42 GTP-Binding ProteinCell Cycle ProteinsCells, CulturedCytoskeletonEndothelium, VascularGTP PhosphohydrolasesGTP-Binding ProteinsIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesPhysical StimulationProtein Serine-Threonine KinasesResponse ElementsRho GTP-Binding ProteinsRhoA GTP-Binding ProteinRho-Associated KinasesTranscription Factor AP-1
1994
Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells
Sumpio B, Widmann M, Ricotta J, Awolesi M, Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal Of Cellular Physiology 1994, 158: 133-139. PMID: 8263020, DOI: 10.1002/jcp.1041580117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell CountCell DivisionEndothelium, VascularPhysical StimulationPressureRatsConceptsSystemic blood pressureCultured endothelial cellsBlood pressureSystemic pressureCell responsesEndothelial cell responsesBovine aortic ECsMorphologic changesEndothelial cellsAortic ECsRat type IEC phenotypeSignificant increaseCell numberEC proliferationVascular systemSignificant regulatory influenceCalf serumEndotheliumType IDigital monitorRegulatory influenceProliferationHg pressureCells
1991
Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch
Iba T, Shin T, Sonoda T, Rosales O, Sumpio B. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. Journal Of Surgical Research 1991, 50: 457-460. PMID: 1903823, DOI: 10.1016/0022-4804(91)90024-g.Peer-Reviewed Original Research
1990
Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch.
Sumpio BE, Widmann MD. Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 1990, 108: 277-81; discussion 281-2. PMID: 2200155.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEndothelinsEndothelium, VascularPeptide BiosynthesisPhysical StimulationPulsatile FlowVasodilationModulation of endothelial cell phenotype by cyclic stretch: Inhibition of collagen production
Sumpio B, Banes A, Link G, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: Inhibition of collagen production. Journal Of Surgical Research 1990, 48: 415-420. PMID: 2352417, DOI: 10.1016/0022-4804(90)90005-m.Peer-Reviewed Original Research