2004
Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases
Lee T, Sumpio BE. Cell signalling in vascular cells exposed to cyclic strain: the emerging role of protein phosphatases. Biotechnology And Applied Biochemistry 2004, 39: 129-139. PMID: 15032733, DOI: 10.1042/ba20030104.Peer-Reviewed Original ResearchConceptsPhosphorylation stateSerine/threonine residuesProtein phosphatase type 2AAbnormal phosphorylation stateCritical cellular functionsPhosphorylation of tyrosineRole of phosphatasesVascular cellsRole of proteinsThreonine residuesCellular functionsProtein kinaseIntracellular proteinsCellular growthHuman diseasesProteinPhosphataseType 2AEndothelial cellsCellsCardiac hypertrophyKinasePhosphorylationHaemodynamic forcesRoleEffects of Cyclic Strain on Vascular Cells
Kakisis JD, Liapis CD, Sumpio BE. Effects of Cyclic Strain on Vascular Cells. Endothelium 2004, 11: 17-28. PMID: 15203876, DOI: 10.1080/10623320490432452.Peer-Reviewed Original ResearchConceptsCAMP-responsive elementVascular cell morphologyExtracellular mechanical signalsMitogen-activated protein kinaseProtein kinase CPlatelet-derived growth factor receptorEarly growth responseCells senseNumerous genesActivator proteinTranscription factorsProtein kinaseGrowth factor receptorAP-2Chemical signalsSecond messengerKinase CG proteinsMechanical signalsCell nucleiGrowth responseIon channelsCell morphologyFactor receptorCell proliferation
1997
Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain
Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. American Journal Of Physiology 1997, 272: c650-c656. PMID: 9124309, DOI: 10.1152/ajpcell.1997.272.2.c650.Peer-Reviewed Original Research
1994
Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells
Wiersbitzky M, Mills I, Sumpio B, Gewirtz H. Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells. Experimental Cell Research 1994, 210: 52-55. PMID: 8269996, DOI: 10.1006/excr.1994.1008.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsAdenylate cyclase activityCoronary vascular smooth muscle cellsMuscle cellsCyclase activityChronic cyclic strainG protein subunit levelsCoronary smooth muscle cellsProtein steady-state levelsCoronary smooth muscleCultured smooth muscle cellsSteady-state levelsPorcine coronary arteriesCoronary arteryCoronary circulationBeta levelsCycles/minProtein subunit levelsSmooth muscleGi alphaIntravascular pressureEffector pathwaysUnstretched cellsSubunit levels
1992
Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro
Widmann M, Letsou G, Phan S, Baldwin J, Sumpio B. Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro. Journal Of Surgical Research 1992, 53: 331-334. PMID: 1405613, DOI: 10.1016/0022-4804(92)90057-7.Peer-Reviewed Original ResearchConceptsRetina-derived growth factorCardiac endothelial cellsEndothelial cellsGrowth factorPure endothelial cellsEC proliferationProliferative responseExogenous growth factorsTrophic effectsRabbit heartsAcetylated LDLCardiac endotheliumCollagenase digestionFetal bovine serumPulsatile strainSignificant increaseBovine serumProliferationEC morphologyCellsRegimenResponseLDLEndotheliumFactorsChanges in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells
Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. American Journal Of Physiology 1992, 262: c956-c962. PMID: 1566821, DOI: 10.1152/ajpcell.1992.262.4.c956.Peer-Reviewed Original Research
1988
Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation.
Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.Peer-Reviewed Original Research