1994
Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications.
Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepatogastroenterology 1994, 41: 573-7. PMID: 7721248.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatic VeinsHumansHypertension, PortalLiver Cirrhosis, AlcoholicMaleMonitoring, IntraoperativePortal PressureProspective StudiesRadiographyRegional Blood FlowRetrospective StudiesSplenic VeinSplenomegalySplenorenal Shunt, SurgicalConceptsCirrhotic patientsPortal pressurePortal hypertensionSplenic embolizationVariceal bleedingHemodynamic basisSpleen sizeDistal splenorenal shuntPortal hypertensive patientsSplenic venous flowVariceal bleedersDefinitive therapyHypertensive patientsSplenorenal shuntSplenic enlargementSplenic veinVenous flowHemodynamic significancePatientsSplenomegalySplenic inflowTreatment implicationsHypertensionBleedingSplenectomy
1988
Variceal Bleeding, Hypersplenism, and Systemic Mastocytosis: Pathophysiology and Management
Sumpio BE, O'Leary G, Gusberg RJ. Variceal Bleeding, Hypersplenism, and Systemic Mastocytosis: Pathophysiology and Management. JAMA Surgery 1988, 123: 767-769. PMID: 3130825, DOI: 10.1001/archsurg.1988.01400300113020.Peer-Reviewed Original ResearchConceptsSystemic mastocytosisType of shuntTissue mast cellsPortal pressure measurementsIntrahepatic fibrosisSatisfactory blockadePortal hypertensionVariceal bleedingPortal pressureShunt surgerySplenic bloodHistamine releaseSurgical diseaseHemodynamic issuesHistamine antagonistsMast cellsDisodium cromoglycateSystemic circulationSystemic effectsAbnormal proliferationMastocytosisUltrastructural studyPressure measurementsHypersplenismHypertension