1993
Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes. Biochemical And Biophysical Research Communications 1993, 190: 576-581. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.Peer-Reviewed Original ResearchConceptsEndothelial cellsAcute hemodynamic changesPhospholipase C activationHemodynamic changesProduction of inositolAcute decreaseAcute increaseIP3 generationEndothelial cell responsesCell responsesIP3 productionPutative mechanotransducersTransient increaseSpecific signal transduction pathwaysOngoing studiesCardiac cycleC activationSignal transduction pathwaysTransduction pathways
1990
Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.
Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. The Journal Of Cardiovascular Surgery 1990, 31: 634-9. PMID: 2229164.Peer-Reviewed Original ResearchConceptsEndothelial cellsAdenylate cyclaseAdenylate cyclase activityEndothelial cell functionVascular endothelial cellsAortic endothelial cellsCultured endothelial cellsMembrane adenylate cyclaseTime-dependent increaseBovine aortic endothelial cellsHemodynamic changesCardiac outputRate of proliferationStretch receptorsCulture wellsPulsatile stretchingStatic culture techniquesPulsatile stressCrude membrane preparationsCyclase activityCell functionVascular biologySecretion of macromoleculesCyclasePulsatile nature