1994
Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells
Sumpio B, Widmann M, Ricotta J, Awolesi M, Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal Of Cellular Physiology 1994, 158: 133-139. PMID: 8263020, DOI: 10.1002/jcp.1041580117.Peer-Reviewed Original ResearchConceptsSystemic blood pressureCultured endothelial cellsBlood pressureSystemic pressureCell responsesEndothelial cell responsesBovine aortic ECsMorphologic changesEndothelial cellsAortic ECsRat type IEC phenotypeSignificant increaseCell numberEC proliferationVascular systemSignificant regulatory influenceCalf serumEndotheliumType IDigital monitorRegulatory influenceProliferationHg pressureCells
1993
Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes. Biochemical And Biophysical Research Communications 1993, 190: 576-581. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.Peer-Reviewed Original ResearchConceptsEndothelial cellsAcute hemodynamic changesPhospholipase C activationHemodynamic changesProduction of inositolAcute decreaseAcute increaseIP3 generationEndothelial cell responsesCell responsesIP3 productionPutative mechanotransducersTransient increaseSpecific signal transduction pathwaysOngoing studiesCardiac cycleC activationSignal transduction pathwaysTransduction pathways