2016
Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy
Haser GC, Sumpio B. Systemic and cell-specific mechanisms of vasculopathy induced by human immunodeficiency virus and highly active antiretroviral therapy. Journal Of Vascular Surgery 2016, 65: 849-859. PMID: 26994951, DOI: 10.1016/j.jvs.2016.01.036.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusActive antiretroviral therapySmooth muscle cellsAntiretroviral therapyHIV patientsImmunodeficiency virusTraditional cardiovascular risk factorsMuscle cellsEndothelial cellsCardiovascular risk factorsChronic immune activationSerious cardiovascular eventsDevelopment of atherosclerosisVascular systemCardiovascular eventsVascular complicationsHIV medicationsChronic inflammationImmune activationMyocardial infarctionRisk factorsCell-specific mechanismsGeneral populationCholesterol metabolismCardiovascular pathology
2012
Contemporary Evaluation and Management of the Diabetic Foot
Sumpio BE. Contemporary Evaluation and Management of the Diabetic Foot. Scientifica 2012, 2012: 435487. PMID: 24278695, PMCID: PMC3820495, DOI: 10.6064/2012/435487.Peer-Reviewed Original ResearchDiabetic footNegative pressure wound therapyMajor public health issueMainstay of therapyDiabetic foot diseaseGood functional outcomeHospitalization of patientsHealth care workersPressure wound therapyTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAggressive debridementSuperimposed infectionFrequent debridementLimb salvageFoot ulcersChronic inflammationCostly complicationFunctional outcomeFoot problemsIschemic limbsDiabetic Foot Ulceration and Management
Blume P, Jain A, Sumpio B. Diabetic Foot Ulceration and Management. Contemporary Diabetes 2012, 63-91. DOI: 10.1007/978-1-62703-158-5_6.Peer-Reviewed Original ResearchFoot ulcersMajor public health issueGrowth factorDiabetic foot diseaseDiabetic foot ulcerationHospitalization of patientsGood clinical careTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAdjuvant therapySuperimposed infectionFoot ulcerationFrequent debridementLimb salvagePathophysiologic mechanismsChronic inflammationDiabetic footCostly complicationFoot problemsIschemic limbsClinical trials