2010
Thrombospondin 1, Fibronectin, and Vitronectin are Differentially Dependent Upon RAS, ERK1/2, and p38 for Induction of Vascular Smooth Muscle Cell Chemotaxis
Willis AI, Sadowitz B, Fuse S, Maier KG, Lee TS, Wang XJ, Tuszynski GP, Sumpio BE, Gahtan V. Thrombospondin 1, Fibronectin, and Vitronectin are Differentially Dependent Upon RAS, ERK1/2, and p38 for Induction of Vascular Smooth Muscle Cell Chemotaxis. Vascular And Endovascular Surgery 2010, 45: 55-62. PMID: 21193465, DOI: 10.1177/1538574410387677.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsCattleCells, CulturedChemotaxisFibronectinsHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularMyocytes, Smooth MuscleP38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsRas ProteinsThrombospondin 1TransfectionVitronectinConceptsVascular smooth muscle cellsThrombospondin-1Smooth muscle cell chemotaxisFarnesyl protein transferase inhibitorSignal transduction pathwaysProtein transferase inhibitorsVascular smooth muscle cell chemotaxisBovine vascular smooth muscle cellsTSP-1Ras N17Transduction pathwaysSecond messenger systemsP38Smooth muscle cellsERK1/2VSMC migrationTransferase inhibitorsPD098059Cell chemotaxisSB202190Muscle cellsMessenger systemsVitronectinRAChemotaxis
2001
Cyclic Stretch Induces the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells
Smith JD, Davies N, Willis AI, Sumpio BE, Zilla P. Cyclic Stretch Induces the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells. Endothelium 2001, 8: 41-48. PMID: 11409850, DOI: 10.3109/10623320109063156.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicCattleCells, CulturedCoculture TechniquesCulture MediaEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationLymphokinesMuscle, Smooth, VascularPhosphorylationReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorStress, MechanicalVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilationConceptsVascular smooth muscle cellsVascular endothelial growth factorSmooth muscle cellsEndothelial growth factorExposure of VSMCsMuscle cellsGrowth factorMigration of ECsBovine vascular smooth muscle cellsSteady-state levelsCyclic stretchNormal endothelial cell functionEndothelial cell functionVEGF receptor KDRRelease of VEGFVEGF receptor phosphorylationVEGF secretionMRNA steady-state levelsVEGF receptorsReceptor KDRVEGF mRNACell functionReceptor phosphorylationSignificant increaseEC survival