2008
Regulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8EndometriosisRegulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli U, Selam B, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular Human Reproduction 2004, 10: 393-398. PMID: 15073283, DOI: 10.1093/molehr/gah060.Peer-Reviewed Original ResearchConceptsStromal cell survivalCell survivalStromal cellsVascular endothelial growth factorEndometrial stromal cellsPotent mitogenic cytokineFasL expressionGrowth factorRegulation of FasLApoptotic signalingTranslation levelsFas ligand expressionWestern blot analysisEndothelial growth factorFas receptorFasL levelsBlot analysisFas ligandExpression of FasLConcentration-dependent mannerMitogenic cytokinesEffects of VEGFRegulationExpressionParacrine manner
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysis
1999
Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion
Garcia-Velasco J, Arici A. Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion. Molecular Human Reproduction 1999, 5: 1135-1140. PMID: 10587368, DOI: 10.1093/molehr/5.12.1135.Peer-Reviewed Original ResearchRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1
Garcia-Velasco J, Seli E, Arici A. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1. Biology Of Reproduction 1999, 61: 548-552. PMID: 10411539, DOI: 10.1095/biolreprod61.2.548.Peer-Reviewed Original ResearchConceptsCell adhesionExtracellular matrix connectionsActin cytoskeletonMCP-1 regulationGene expressionIntegrin activationECM substratesProtein secretionStromal cell adhesionCytochalasin DCell typesMCP-1 gene expressionNovel mechanismHuman endometrial stromal cellsMonocyte chemotactic protein-1 expressionProtein levelsIntegrinsProtein-1 expressionAdhesion matrixRegulationExpressionStromal cellsESC adhesionEndometrial stromal cellsCollagen IVInterleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Garcia-Velasco J, Arici A. Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertility And Sterility 1999, 72: 336-340. PMID: 10439007, DOI: 10.1016/s0015-0282(99)00223-x.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInterleukin-8IL-8 monoclonal antibodyStromal cellsMonoclonal antibodiesBenign gynecologic surgeryPathogenesis of endometriosisConcentration-dependent increaseConcentration-dependent mannerEndometrial implantsEndometrial diseaseGynecologic surgeryMAIN OUTCOMEAntibodiesStromal cell adhesionAdhesion assaysAcademic research laboratoriesCellsCell adhesionEndometriosisSurgeryPathogenesisDiseaseWomenProgesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populations
1998
Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factors
1997
Growth‐Regulated α Expression in Human Preovulatory Follicles and Ovarian Cells
Oral E, Seli E, Bahtiyar M, Jones E, Arici A. Growth‐Regulated α Expression in Human Preovulatory Follicles and Ovarian Cells. American Journal Of Reproductive Immunology 1997, 38: 19-25. PMID: 9266006, DOI: 10.1111/j.1600-0897.1997.tb00271.x.Peer-Reviewed Original ResearchConceptsGRO-alpha levelsGranulosa-lutein cellsGRO-alpha productionGRO alphaFollicular fluidGRO-alpha mRNAAlpha productionPg/Stromal cellsAlpha levelsAlpha mRNAHuman preovulatory folliclesOvarian stromal cellsPeriovulatory follicular fluidProcess of ovulationTime of ovulationInterleukin-alphaTumor necrosisNeutrophil chemotaxisNeutrophil increaseΑ expressionPreovulatory folliclesGranulosa-luteinOvarian cellsPost-hCGMonocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells
Arici A, Oral E, Bukulmez O, Buradagunta S, Bahtiyar O, Jones E. Monocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells. Journal Of Reproductive Immunology 1997, 32: 201-219. PMID: 9080384, DOI: 10.1016/s0165-0378(97)82476-x.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1MCP-1 levelsFollicular fluidHCG administrationPreovulatory folliclesPg/Granulosa-lutein cell culturesSerum MCP-1 levelsMacrophage migrationMCP-1 mRNA expressionChemotactic protein-1 expressionAdministration of hCGHuman preovulatory folliclesSerum progesterone levelsChemotactic protein-1Human ovarian folliclesFollicular fluid samplesHuman follicular fluidGranulosa-lutein cellsLH/hCGInterleukin-1 alphaMonocytes/macrophagesProtein-1 expressionMCP-1 mRNAPg/mL
1996
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube
Keltz M, Attar E, Buradagunta S, Olive D, Kliman H, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-1619. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood Physiological PhenomenaCells, CulturedCulture MediaCytokinesEpitheliumFallopian TubesFemaleGene Expression RegulationGrowth InhibitorsGrowth SubstancesHormonesHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPregnancyPregnancy, EctopicRNA, MessengerStromal CellsConceptsLeukemia inhibitory factor expressionLeukemia inhibitory factorFallopian tubeInhibitory factorStromal cellsEctopic pregnancyStromal cell culturesGrowth factorMessenger ribonucleic acidLeukemia inhibitory factor gene expressionEctopic implantationFactor expressionTubal ectopic pregnancyEpithelial cellsInterleukin-1 alphaHuman fallopian tubePlatelet-derived growth factorMessenger ribonucleic acid levelsRibonucleic acid levelsFactor gene expressionTubal mucosaMenstrual cycleTNF-alphaTumor necrosisCommon siteModulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1
Arici A, MacDonald P, Casey M. Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 3004-3009. PMID: 8768866, DOI: 10.1210/jcem.81.8.8768866.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidEndometrial stromal cellsHuman endometrial stromal cellsMessenger ribonucleic acidIL-8TGF beta 1Stromal cellsChemotactic factorsInterleukin-8 messenger ribonucleic acidT-cell chemotactic factorBone marrow-derived cellsBeta 1Ovarian steroid secretionTGF beta 1 treatmentImmunoreactive IL-8Marrow-derived cellsEndometrium/deciduaInterleukin-8 gene expressionIL-8 geneParacrine-acting factorsOvulatory womenEndometrial decidualizationEndometrial stromaSteroid secretionLeukocyte populationsProgestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells
Arici A, MacDonald P, Casey M. Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells. The Journal Of Steroid Biochemistry And Molecular Biology 1996, 58: 71-76. PMID: 8809187, DOI: 10.1016/0960-0760(96)00016-7.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDactinomycinEndometriumFemaleGene Expression RegulationHumansInterleukin-1Interleukin-8Medroxyprogesterone AcetateMolecular Sequence DataProgesteroneProgesterone CongenersProgestinsProtein Synthesis InhibitorsRecombinant ProteinsRNA, MessengerStromal CellsTranscription, GeneticConceptsIL-8 mRNAHuman endometrial stromal cellsEndometrial stromal cellsInterleukin-8IL-1Stromal cellsInterleukin-8 mRNA levelsNormal human pregnancyIL-8 gene transcriptionFormation of cytokinesMigration of leukocytesConcentration-dependent mannerEndometrial repairHuman pregnancyLeukocytic infiltrationDecidual tissuesHuman endometriumT cellsProgestin regulationSynthetic progestinsUterine endometriumUterine involutionHormonal eventsOvarian cycleEndometriumModulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1
Arici A, MacDonald P, Casey M. Modulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1. Biology Of Reproduction 1996, 54: 463-469. PMID: 8788200, DOI: 10.1095/biolreprod54.2.463.Peer-Reviewed Original ResearchConceptsTGF beta 3 mRNAEndometrial stromal cellsTGF beta 1 mRNATGF beta 1Beta 3 mRNAHuman endometrial stromal cellsBeta 1 mRNAPlatelet-derived growth factorStromal cellsBeta 1Proliferative phase endometrial tissueTGF beta 2 mRNATGF-beta mRNA levelsGrowth factorTGF beta 1 treatmentProliferative phase endometriumEstradiol-17 betaLate secretory phaseSecretory phase tissuesBeta 2 mRNABeta mRNA levelsGrowth factor betaDose-dependent mannerTotal RNATime-dependent fashion
1994
Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells
Marshburn P, Arici A, Casey M. Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells. American Journal Of Obstetrics And Gynecology 1994, 170: 1152-1158. PMID: 8166201, DOI: 10.1016/s0002-9378(94)70112-1.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedDNAEndometriumEstradiolFemaleHumansRNA, MessengerStromal CellsTransforming Growth Factor betaConceptsEstradiol-17 betaEndometrial stromal cellsEndometrial glandsMessenger ribonucleic acidStromal cellsHuman endometriumDeoxyribonucleic acid synthesisGlandular epitheliumEpithelial cellsEndometrial glandular epitheliumEndometrial cell proliferationStromal cell originHuman endometrial cellsGrowth factor-β1Acid synthesisRibonucleic acidSecretory endometriumEndometrial cellsTrichloroacetic acid-precipitable materialEndometrial epitheliumSecretory phaseFactor-β1Cell originAcid-precipitable materialEndometrium