2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8EndometriosisLuteal phase defect: myth or reality
Bukulmez O, Arici A. Luteal phase defect: myth or reality. Obstetrics And Gynecology Clinics Of North America 2004, 31: 727-744. PMID: 15550332, DOI: 10.1016/j.ogc.2004.08.007.Peer-Reviewed Original Research
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisExpression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometrium
1999
Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata
Sozen I, Olive D, Arici A. Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata. Fertility And Sterility 1998, 69: 1095-1102. PMID: 9627299, DOI: 10.1016/s0015-0282(98)00072-7.Peer-Reviewed Original ResearchConceptsMCP-1 mRNA levelsChemotactic protein-1MCP-1Leiomyoma cellsSex steroidsHigher MCP-1 levelsSteroid hormonesMCP-1 protein productionMonocyte chemotactic protein-1MCP-1 levelsMRNA levelsProtein 1Proliferative phase samplesImmunoreactive MCP-1MCP-1 expressionUniversity Medical CenterLeiomyoma cell proliferationParacrine growth factorMCP-1 mRNAGrowth stimulatory effectMessenger RNA levelsPathogenesis of leiomyomaLocal immunityGnRH analoguesProspective study
1996
Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells
Arici A, MacDonald P, Casey M. Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells. The Journal Of Steroid Biochemistry And Molecular Biology 1996, 58: 71-76. PMID: 8809187, DOI: 10.1016/0960-0760(96)00016-7.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDactinomycinEndometriumFemaleGene Expression RegulationHumansInterleukin-1Interleukin-8Medroxyprogesterone AcetateMolecular Sequence DataProgesteroneProgesterone CongenersProgestinsProtein Synthesis InhibitorsRecombinant ProteinsRNA, MessengerStromal CellsTranscription, GeneticConceptsIL-8 mRNAHuman endometrial stromal cellsEndometrial stromal cellsInterleukin-8IL-1Stromal cellsInterleukin-8 mRNA levelsNormal human pregnancyIL-8 gene transcriptionFormation of cytokinesMigration of leukocytesConcentration-dependent mannerEndometrial repairHuman pregnancyLeukocytic infiltrationDecidual tissuesHuman endometriumT cellsProgestin regulationSynthetic progestinsUterine endometriumUterine involutionHormonal eventsOvarian cycleEndometrium