2024
Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching
Raza Q, Nadeem T, Youn S, Swaminathan B, Gupta A, Sargis T, Du J, Cuervo H, Eichmann A, Ackerman S, Naiche L, Kitajewski J. Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching. Scientific Reports 2024, 14: 13603. PMID: 38866944, PMCID: PMC11169293, DOI: 10.1038/s41598-024-64375-z.Peer-Reviewed Original ResearchConceptsNotch signalingEndothelial cell behaviorEndothelial junctionsCell behaviorMultiple endothelial cell typesStabilization of endothelial junctionsNotch activationEndothelial Notch signalingTarget of Notch signalingTranscriptional activation complexEndothelial cell typesPlexus branchesVascular densityEndothelial proliferationBrain endotheliumMouse retinaIn vivo targetingEffector proteinsVascular outgrowthJunction activityNotch proteinsEndothelial cellsExcessive vascularizationDownstream effectorsEndothelial gene expression
2007
The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, del Toro R, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching. The FASEB Journal 2007, 21: a15-a15. DOI: 10.1096/fasebj.21.5.a15-a.Peer-Reviewed Original ResearchTip cell formationEndothelial tip cell formationTip cellsCell formationNovel negative regulatorCell marker genesEndothelial tip cellsLigand Delta-like 4Severe vascular abnormalitiesVessel branchingDelta-like 4Notch ligand Delta-like 4Embryonic lethalExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNotch signalingNegative regulatorAngiogenic sproutingVEGF stimulationVEGF receptor 2Filopodia extensionGenetic background