Analysis of the impact of eliminating bolus 5-fluorouracil in metastatic colorectal cancer.
Peng C, Saffo S, Shusterman M, Becker D, Berlin J, Oberstein P, Nagar A, Yu S. Analysis of the impact of eliminating bolus 5-fluorouracil in metastatic colorectal cancer. Journal Of Clinical Oncology 2023, 41: 59-59. DOI: 10.1200/jco.2023.41.4_suppl.59.Peer-Reviewed Original ResearchMetastatic colorectal cancerOverall survivalECOG scoreColorectal cancerUnivariable Cox proportional hazards modelsFirst-line treatment regimensCox proportional hazards modelHigh-risk comorbiditiesHigher ECOG scoreRole of bolusMulticenter cohort studyOverall survival benefitRisk of deathLimited functional statusCombination drug regimenProportional hazards modelUse of bolusPropensity-score matchingAdjuvant settingBaseline creatinineFlatiron HealthMedian followCohort studyCreatinine levelsDrug regimen