2017
IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer
Wang L, Miyahira A, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J, Lee P. IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 2017, 77: 1119-1126. PMID: 27879265, PMCID: PMC5334262, DOI: 10.1158/0008-5472.can-16-1373.Peer-Reviewed Original ResearchConceptsPeripheral blood T cellsBreast cancer patientsBlood T cellsCancer patientsT cellsIL6 levelsWorse relapse-free survivalPlasma IL6 levelsCancer cellsRelapse-free survivalSerum IL6 levelsAnti-inflammatory propertiesHost immune responseInvolved downregulationClinical outcomesPredictive biomarkersImmune responsePleiotropic cytokinePatientsIL6Cancer ResCancer progressionSurvivalDiagnosisCells
2013
Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients
Chang A, Bhattacharya N, Mu J, Setiadi A, Carcamo-Cavazos V, Lee G, Simons D, Yadegarynia S, Hemati K, Kapelner A, Ming Z, Krag D, Schwartz E, Chen D, Lee P. Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients. Journal Of Translational Medicine 2013, 11: 242. PMID: 24088396, PMCID: PMC3852260, DOI: 10.1186/1479-5876-11-242.Peer-Reviewed Original ResearchConceptsBreast cancer patientsLymph nodesCancer patientsImmune cellsT cellsDendritic cellsIntra-mammary lymph nodesAnti-tumor immune responseDC cancer vaccinesKaplan-Maier analysisDisease-free survivalLog-rank testClinical outcome analysisT cell interactionsIntra-group comparisonInter-group comparisonMann-Whitney testDC clustersBackgroundDendritic cellsDC clusteringClinical outcomesCancer vaccinesSurvival outcomesDC functionNon-parametric Mann-Whitney test