2024
Preintervention Wait Time and Survival in People With Rheumatic Heart Disease in Uganda
Doh C, An C, Chang A, Rwebembera J, Mwambu T, Beaton A, Nakagaayi D, Ruda Vega P, Sable C, Longenecker C, Lwabi P. Preintervention Wait Time and Survival in People With Rheumatic Heart Disease in Uganda. The Annals Of Thoracic Surgery 2024, 118: 941-948. PMID: 38908768, DOI: 10.1016/j.athoracsur.2024.06.009.Peer-Reviewed Original ResearchRheumatic heart diseaseSurgical interventionRisk factors associated with timeClinical rheumatic heart diseaseFactors associated with timeAtrial fibrillationNew York Heart Association functional class III/IVYears of follow-upHeart diseaseCox proportional hazards modelsHistory of infective endocarditisHistory of atrial fibrillationMultivariate Cox proportional hazards modelFunctional class III/IVPre-interventionRight ventricular dysfunctionProportional hazards modelAssociated with increased probabilityProbability of deathEducation levelKaplan-Meier estimatesSurgical burdenPreoperative mortalityValve surgeryClass III/IVOutcomes and care quality metrics for people living with rheumatic heart disease and atrial fibrillation in Uganda
Opara C, Lan R, Rwebembera J, Okello E, Watkins D, Chang A, Longenecker C. Outcomes and care quality metrics for people living with rheumatic heart disease and atrial fibrillation in Uganda. Heart Rhythm O2 2024, 5: 201-208. PMID: 38690140, PMCID: PMC11056452, DOI: 10.1016/j.hroo.2024.02.002.Peer-Reviewed Original ResearchRheumatic heart diseaseCare retentionAtrial fibrillationFactors associated with retentionCare quality metricsNearest health centerNew York Heart Association functional class III/IVComplications of rheumatic heart diseaseLower-resource settingsHeart diseaseFunctional class III/IVMultivariate logistic regressionMedian follow-upCare metricsHealth centersPrescription ratesCareConcurrent AFAnticoagulant prescriptionLogistic regressionClass III/IVAF participantsMedian ageAtrial flutterCharacterize demographics
2023
Abstract 14916: Clinical and Socioeconomic Factors Associated With Time to Surgery and Preoperative Mortality in Surgery-Eligible Patients With Rheumatic Valvular Heart Disease in Uganda
Doh C, An C, Chang A, Rwebembera J, Mwambu T, Beaton A, Nakagaayi D, Vega P, Sable C, Lwabi P, Longenecker C. Abstract 14916: Clinical and Socioeconomic Factors Associated With Time to Surgery and Preoperative Mortality in Surgery-Eligible Patients With Rheumatic Valvular Heart Disease in Uganda. Circulation 2023, 148: a14916-a14916. DOI: 10.1161/circ.148.suppl_1.14916.Peer-Reviewed Original ResearchRheumatic heart diseaseFactors associated with timeLikelihood of surgeryPreoperative mortalitySurgical indicationsAwaiting surgeryAtrial fibrillationIncreased likelihood of surgeryValvular rheumatic heart diseaseHistory of infective endocarditisHistory of atrial fibrillationMultivariate Cox proportional hazards modelAdvanced rheumatic heart diseaseHeart diseaseRate of surgical interventionRheumatic valvular heart diseaseNYHA class I/IISurgery-eligible patientsNYHA class III/IVMedian follow-upAssociated with increased mortalityTime to surgeryCohort of patientsReceipt of surgeryValvular heart disease
2018
Association of Healthcare Plan with atrial fibrillation prescription patterns
Chang A, Askari M, Fan J, Heidenreich P, Ho P, Mahaffey K, Ullal A, Perino A, Turakhia M. Association of Healthcare Plan with atrial fibrillation prescription patterns. Clinical Cardiology 2018, 41: 1136-1143. PMID: 30098034, PMCID: PMC6489790, DOI: 10.1002/clc.23042.Peer-Reviewed Original ResearchConceptsNon-vitamin K-dependent oral anticoagulantsPrimary care physiciansAtrial fibrillationHealthcare planningOral anticoagulantsPlanned patientsOdds of OAC prescriptionAF diagnosisPrescription of oral anticoagulantsRhythm control agentsRhythm control medicationsRetrospective cohort studyAF treatment strategiesReceipt of therapyPharmaceutical claims databaseAssociated with lower useIndex AF diagnosisReceipt of medicationsOAC prescriptionMedian timeLogistic regression modelsAF therapyPrescription patternsTreatment strategiesCohort study2135 Impact of primary care physician gatekeeping on medication prescriptions for atrial fibrillation
Chang A, Askari M, Fan J, Heidenreich P, Ho P, Mahaffey K, Perino A, Turakhia M. 2135 Impact of primary care physician gatekeeping on medication prescriptions for atrial fibrillation. Journal Of Clinical And Translational Science 2018, 2: 82-83. PMCID: PMC6799225, DOI: 10.1017/cts.2018.287.Peer-Reviewed Original ResearchPrimary care physiciansReceipt of medicationsNon-vitamin K-dependent oral anticoagulantsCare physiciansHealth plansImpact of primary care physiciansAssociated with clinically meaningful differencesController medicationsOdds ratioRhythm control agentsAF diagnosisCalculate adjusted odds ratiosOral anticoagulantsRhythm control medicationsStatistically significant lower oddsStatistically significant odds ratiosAdjusted odds ratiosAtrial fibrillationRate control agentsMultivariate logistic regression modelPharmaceutical claims databaseSignificant odds ratioLogistic regression modelsSignificantly lower oddsOral anticoagulant prescriptions
2014
Evaluating the Cost-effectiveness of Catheter Ablation of Atrial Fibrillation.
Chang A, Kaiser D, Ullal A, Perino A, Heidenreich P, Turakhia M. Evaluating the Cost-effectiveness of Catheter Ablation of Atrial Fibrillation. Arrhythmia & Electrophysiology Review 2014, 3: 177-83. PMID: 26835088, PMCID: PMC4711535, DOI: 10.15420/aer.2014.3.3.177.Peer-Reviewed Original ResearchAtrial fibrillationCatheter ablation of atrial fibrillationConventional antiarrhythmic drug therapyAblation of atrial fibrillationAssociated with considerable morbidityQuality of lifeCost-effectiveness analysisAntiarrhythmic drug therapyFirst-line therapyAF ablationPulmonary veinsCatheter ablationSinus rhythmDrug therapyCardiology settingCardiac conditionsProcedural costsCost-effectiveSurrounding tissuesTherapyHealthcare utilisationPrimary careAblationFibrillation