2013
Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging
Glahn DC, Kent JW, Sprooten E, Diego VP, Winkler AM, Curran JE, McKay DR, Knowles EE, Carless MA, Göring HH, Dyer TD, Olvera RL, Fox PT, Almasy L, Charlesworth J, Kochunov P, Duggirala R, Blangero J. Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19006-19011. PMID: 24191011, PMCID: PMC3839730, DOI: 10.1073/pnas.1313735110.Peer-Reviewed Original Research
2012
Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression
Kochunov P, Glahn DC, Rowland LM, Olvera RL, Winkler A, Yang YH, Sampath H, Carpenter WT, Duggirala R, Curran J, Blangero J, Hong LE. Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression. Biological Psychiatry 2012, 73: 482-491. PMID: 23200529, PMCID: PMC3645491, DOI: 10.1016/j.biopsych.2012.10.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD cohortAge-related declineFractional anisotropyWM tractsFA valuesAge interactionMain outcome measuresCerebral white matterPathophysiology of schizophreniaAverage fractional anisotropyWhite matter integrityCerebral WMMajor WM tractsMDD patientsDepressive disorderMajor depressionOutcome measuresFunctional declineSCZ patientsWhite matterCohortPeak myelinationPatientsWM FA values
2010
Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure
Kochunov P, Glahn D, Lancaster J, Winkler A, Kent JW, Olvera RL, Cole SA, Dyer TD, Almasy L, Duggirala R, Fox PT, Blangero J. Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure. Stroke 2010, 41: 2137-2142. PMID: 20724716, PMCID: PMC3084627, DOI: 10.1161/strokeaha.110.590943.Peer-Reviewed Original ResearchA Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore component
2009
Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume
Kochunov P, Glahn D, Winkler A, Duggirala R, Olvera RL, Cole S, Dyer TD, Almasy L, Fox PT, Blangero J. Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume. Stroke 2009, 40: 3685-3690. PMID: 19834011, PMCID: PMC2787844, DOI: 10.1161/strokeaha.109.565390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingBiomarkersBrain IschemiaCerebrospinal Fluid PressureCerebrumChromosome MappingCohort StudiesDisease ProgressionDNA Mutational AnalysisEpendymaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic TestingGenetic VariationHumansIntracranial HypertensionLeukoencephalopathiesMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNerve Fibers, MyelinatedYoung AdultConceptsArterial pulse pressurePulse pressureImportant neuroimaging markerFluid-attenuated inversion recovery imagesCommon risk factorsWhite matter volumeYears of ageInversion recovery imagesHealthy Mexican AmericansHWM volumeFamily Heart StudyRisk factorsCerebral volumeNeuroimaging markerHeart StudyMatter volumeWhite matterWhole brainPathophysiology studiesCerebral integritySan Antonio Family Heart StudyRecovery imagesMexican AmericansWhole-genome linkageGenome linkage