2019
One-year changes in brain microstructure differentiate preclinical Huntington's disease stages
Pflanz C, Charquero-Ballester M, Majid D, Winkler A, Vallée E, Aron A, Jenkinson M, Douaud G. One-year changes in brain microstructure differentiate preclinical Huntington's disease stages. NeuroImage Clinical 2019, 25: 102099. PMID: 31865023, PMCID: PMC6931230, DOI: 10.1016/j.nicl.2019.102099.Peer-Reviewed Original ResearchConceptsOnset of symptomsPreclinical stageDisease stageMean diffusivityHuntington's diseaseGender-matched healthy controlsOnly clinical measurePosterior basal gangliaDistinct pathophysiological mechanismsOptimal therapeutic windowOne-year changeSignificant differencesPreclinical Huntington's diseasePresymptomatic Huntington's diseaseNeurodegenerative phaseNeuroinflammatory processesMotor scoresPathophysiological mechanismsBasal gangliaDisease progressionHealthy controlsHuntington's disease stagesCorpus callosumTreatment responseClinical measures
2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation